[Effects of pathogenetic therapy on blood cholesterol in patients with glomerulonephritis].

Aim: To evaluate effects of corticosteroids, cytostatics, ACE inhibitors, Ang-II receptor blockers, HMG-CoA-reductase inhibitors on the levels of blood cholesterol in patients with progressive glomerulonephritis (PGN).

Material And Methods: The influence of medications which are used for treatment of chronic glomerulonephritis on the serum levels of total cholesterol (TCh) was investigated in 53 patients with chronic glomerulonephritis and persistent nephrotic syndrome (NS). All the patients with NS or nephrotic range proteinuria were divided into five groups depending on the type of therapy: corticosteroids, cytotoxic agents, ACE inhibitors, Ang-II receptor blocker, HMG-CoA-reductase inhibitors.

Chronology of labyrinthitis ossificans induced by Streptococcus pneumoniae meningitis.

Objective: Labyrinthitis ossificans consists of novel osteogenesis that fills the normally patent cochlear and vestibular lumen as an end-stage sequelae to various pathologies. This study was designed to establish the sequence of events and chronology of the osteoneogenesis and calcification.

Study Design: A prospective randomized double-blind study.

HDL causes mesangial cell mitogenesis through a tyrosine kinase-dependent receptor mechanism.

Hypercholesterolemia and mesangial cell proliferation have been proposed to play a role in the progression of glomerulosclerosis in diabetic nephropathy and other renal diseases. Although LDL is mitogenic for and cytotoxic to mesangial cells, the effect of HDL on these cells is unknown. HDL stimulates fibroblast mitogenesis and is the principal cholesterol-bearing lipoprotein in the rat, the experimental model for studying the effect of hyperlipidemia on renal disease.

[Urinary enzymes in the assessment of the early stage of kidney involvement in psoriasis and diabetes mellitus].

The activity of gamma-glutamyl transferase (GGT), alkaline phosphatase (AP), lactate dehydrogenase (LDG), N-acetyl-beta-D-glucosaminidase (NAG) was assessed in 53 patients with psoriasis (PS), 24 PS patients with affected kidneys, 50 patients with type 1 diabetes mellitus(DM). Enhanced activity of the enzymes occurred not only in nephropathy patients but also in those without proteinuria. AP and NAG were more active in PS, while LDG and NAG in DM.

[Means for the inhibition of the nonimmune progression of nephritis].

Inhibition of non-immune progression of renal insufficiency for control of glomerulonephritis was attempted via hemodynamic, metabolic and hypolipidemic means. Hemodynamic correction was conducted using inhibitors of angiotensin-converting enzyme capoten and renitek. The action on metabolic factors of progression was realized by lovastatin mevakor.

[Antihyperlipidemic actions in the treatment of nephropathies].

In view of weak implication of immunoinflammatory mechanisms in pathogenesis of noninflammatory nephropathy one may expect the disease course improvement and more slow progression of renal dysfunction. The mechanism of this action can be realized through hypolipidemic effect. In recent research there are data on a direct lovastatin action on the mechanism underlying nephritis progression by means of inhibiting proliferation of mesangial cells.

[Hyperlipidemia and glomerulosclerosis in nephropathies: clinicomorphological comparisons].

An extracellular matrix (collagens I, III, IV) was studied in the glomeruli of patients demonstrating glomerular low density lipoproteins (LDL) and free of them. These two patients' groups were not found significantly different by age, nephropathy duration, blood pressure, serum concentrations of creatinine, triglycerides, HDL cholesterol. The LDL deposit group differed by longer duration of the nephrotic syndrome, higher 24-h proteinuria, lower serum albumin levels, higher total cholesterol in the serum and the proportion VLDL and LDL cholesterol to HDL cholesterol.

[Urinary tests for inflammation in glomerulonephritis].

Boyden camera tests, chemiluminescence of urinary supernatant, passive hemagglutination tests were used in measuring chemotactic properties of the urine, intensity of free-radical processes, fibronectin urine concentrations, respectively, in 31 glomerulonephritis (GN) patients. The above parameters were closely related to nephritis activity. These were much lower in patients with nephritis remission, than in subjects with nephrotic syndrome or exacerbation of latent nephritis.

[Hyperlipidemia as a factor in the development and progress of diabetic nephropathy].

Twenty-nine patients with insulin-dependent diabetes mellitus with similarly manifest renal involvement were examined to elucidate the role of dyslipidemia in diabetic nephropathy progress. Clinico-laboratory parameters (urinary albumin excretion, blood serum levels of total cholesterol, triglycerides, low, very low, and high density lipoprotein cholesterol) and morphologic changes in renal tissue biopsy specimens were analyzed. An increment of the number of large lipid incorporations was observed in various cells of renal glomeruli and interstitium, as well as a high prevalence of low density lipoprotein deposition in glomerular basal membranes and canaliculi as the renal process augmented in severity.

[The role of intraglomerular hypertension and lipids in the development of diabetic nephropathy].

To determine the mechanisms underlying diabetic nephropathy (DN) onset, a clinical and morphological study was initiated of 14 diabetics with insulin-dependent disease free of clinical renal manifestations. The patients were examined for intraglomerular hypertension, blood lipid spectrum and renal tissue morphology. In high intraglomerular hypertension, i.

[Blood lipids in renal amyloidosis].

Serum lipids were estimated in patients with renal amyloidosis (RA): 21 with familial Mediterranean fever (FMF) and 24 with secondary renal amyloidosis versus FMF patients without renal dysfunction or having chronic glomerular nephritis. All the RA patients had dyslipidemia of atherogenic nature the severity of which correlated with that of renal disorder. Our results showed the presence of dyslipidemia early during RA course.

[Lipiduria in the nephrotic syndrome].

A study was made of urine lipids and their fractions in chronic glomerulonephritis (CGN) and renal amyloidosis with nephrotic syndrome (NS). 91 patients suffering from NS were examined. 2 subgroups were distinguished among these patients: with CGN of the nephrotic type and with the nephrotic stage of renal amyloidosis.

[Hypotensive therapy and the level of blood lipids in patients with chronic nephritis associated with arterial hypertension].

A study was made of the content of blood lipids in patients with associated chronic nephritis and arterial hypertension (AH). It has been established that the reduction of arterial pressure as a result of hypotensive therapy (administration of central action drugs, vasodilators of direct action, calcium antagonists, blockers of the angiotensin-transforming enzyme) was followed by a decrease in the blood of the concentration of fatty acids, glycerin, triglycerides, low density lipoproteins, total cholesterol, free cholesterol, phospholipids, characteristics of lipid peroxidation and by the rise of cholesterol concentration in high density lipoproteins. The data obtained are of clinical importance in view of the possibility of correcting dyslipidemia in patients with associated chronic nephritis and arterial hypertension during hypotensive treatment.

[Arterial hypertension and fatty acids of the blood in patients with chronic glomerulonephritis without the nephrotic syndrome].

The study involved 33 patients with chronic glomerulonephritis of hypertonic type (CGNHT), in their number 8 with the signs of a moderate renal failure, 25 with a latent form of the disease (CGNLF), 10 ones with hypertension, and 20 healthy age-matched subjects. Patients with CGNHT and hypertension patients were comparatively studies for the blood pressure values. Fatty acid, glycerine, malonic dialdehyde contents were investigated in all the examinees.

[Content of basic lipid classes in the blood plasma of patients with the renal hypertensive syndrome].

The main classes of serum lipids (fatty acids, phospholipids, triglycerides, cholesterol) were studied and compared in 36 patients aged 20 to 41 years with the renal hypertensive syndrome of different etiology, in 25 patients aged 30 to 51 years with essential hypertension, and in 20 practically healthy subjects aged 20 to 42 years. The mechanism of changes in the content of serum lipids in different diseases associated with the hypertensive renal syndrome and in patients with essential hypertension allows an assumption that these changes are linked to a large degree with arterial hypertension.