The role of S100P and IMP3 in the cytologic diagnosis of pancreatic adenocarcinoma.

Purpose: The aim of this study was to assess the role of the two markers, S100P and IMP3, in differentiating between pancreatic ductal adenocarcinoma (PDA) and non-neoplastic pancreatic tissue in (fine needle aspiration cytology) FNAC.

Patients And Methods: This is a retrospective study that included 72 cases presented with pancreatic mass, where endoscopic guided FNAC was taken from pancreatic lesions. The final histopathologic diagnosis was considered the gold standard.

Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma: Relationship with clinicopathological parameters.

Background: Gastric cancer is one of the most common cancers and the second most common cause of cancer-related death worldwide. Identification of specific prognostic indicators might allow a better prognostic stratification and more effective therapy.

Aim: To assess the expression and relationship between COX-2 and VEGF protein in gastric adenocarcinoma and whether these markers are useful in predicting clinicopathological prognostic parameters.

Diagnostic value of p53 and ki67 immunostaining for distinguishing benign from malignant serous effusions.

Background: The differentiation of benign mesothelial cells from malignant tumor cells, primary, or metastatic, in serous effusions based on cytomorphologic features alone can be problematic.

Purpose: This study was conducted to evaluate the utility of p53 and ki67 immunocytochemical markers in differentiating benign from malignant tumor cells in serous effusions.

Patients And Methods: Archival Papanicolaou-stained smears of 91 pleural and peritoneal effusions were retrieved from Cytology Unit, Pathology Department, NCI, Cairo University between 2008 and 2010.

Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy.

Purpose: The aim of this work is to evaluate the reliability and diagnostic accuracy of fine needle aspiration cytology (FNAC) of cervical lymph nodes with an emphasis on discordant cases between the cytology and the histopathology.

Patients And Methods: This retrospective study was conducted on 157 selected patients with cervical lymphadenopathy that had undergone FNAC. Cervical nodal enlargement was the first clinical manifestation of the patients in all cases.

Assessment of the reliability of immunocytochemical detection of estrogen and progesterone receptors status on the cytological aspirates of breast carcinoma.

Purpose: Evaluation of the reliability of immunocytochemical staining for estrogen and progesterone receptor status on previously papanicolaou-stained fine needle aspiration smears of breast carcinoma cases.

Patients And Methods: This is a retrospective study conducted on destained smears of fine needle aspirates (FNA) obtained from 90 breast carcinoma cases. These cases underwent subsequent tumor resection and immunohistochemical detection of estrogen and progesterone receptors allowing a comparison between the immunocytochemical and immunohistochemical results (Gold Standard).

The Role of P63 Immunocytochemistry for Myoepithelial Cells in the Diagnosis of Atypical and Suspicious Cases in Breast Fine Needle Aspiration Cytology (FNAC).

Purpose: Evaluation of the usefulness of p63 immunocytochemical marker for myoepithelial cells in the diagnosis of atypical and suspicious lesions in breast cytology.

Patients And Methods: This is a retrospective study on 122 selected patients presented at Cytology Unit, Pathology Department, NCI, Cairo University, in three years interval from 2007 to 2009, with breast lumps who underwent preoperative FNAC and diagnosed cytologically as atypical or suspicious breast lesion for biopsy then they were followed by excisional biopsy for histopathologic assessment that was considered as the golden standard diagnosis against which FNAC diagnoses were compared. Paucicellular cytologic slides as well as cases with no corresponding final histopathological diagnosis were excluded.

Evaluation of the Value of Combined Urine Cytology and Cystoscopy for Follow-up of Superficial Transitional Cell Carcinoma of the Urinary Bladder.

Objective: Cystoscopic biopsy is the most accurate technique used to assess the efficacy of treatment and to detect recurrence of superficial TCC of urinary bladder. Implementation of voided urine cytology to detect tumor cells in urine samples may represent an additional tool. The aims of this study are: (1) To estimate the reliability of combined cystoscopy and urine cytology examination in the follow-up of cases of superficial urinary bladder carcinoma, which might help to restrict cystoscopic biopsies for these cases with its morbidity and cost, (2) To discuss the diagnostic pitfalls of cytologic examination in these cases.