Publications by authors named "Neus Solanes"
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motoneurons with no known effective treatments.
- Recent research highlights the role of Neuregulin 1 (NRG1) isoforms, particularly NRG1-I in muscle repair and NRG1-III in motoneuron survival, suggesting they could be targets for new therapies.
- In a study involving SOD1 transgenic mice, overexpression of NRG1-I in skeletal muscles improved motoneuron survival, boosted neuromuscular junctions, reduced spinal cord inflammation, and delayed disease onset, indicating NRG1's potential in treating ALS.
Genes Chromosomes Cancer
November 2017
Article Synopsis
- - The study examines genetic changes in relapsed adult acute lymphoblastic leukemia (ALL), finding a high degree of genetic diversity without a clear relapse pattern, despite new treatments.
- - Analysis of samples from 31 adult patients indicated a trend of acquiring specific genetic deletions and an increase in genetic alterations from diagnosis to relapse, particularly involving genes like CDKN2A/B and PAX5.
- - The findings suggest that while the genetics of relapsed ALL is complex and varied, targeting specific deregulated pathways could enhance the effectiveness of current therapies for relapse cases.
