Publications by authors named "Neus Mongay"
Background And Objectives: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).
Methods: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.
Article Synopsis
- Early treatment after a first demyelinating event is linked to improved long-term outcomes in patients with multiple sclerosis (MS), but MR findings are often overlooked when evaluating these outcomes.
- The study analyzed data from 580 patients between 1994 and 2021, categorizing them based on how soon they received disease-modifying drugs (DMDs) after their first event, creating a 5-point MR score (MRS) to assess disability risk.
- Results showed that very early treatment significantly reduced the risk of developing severe disability and secondary progressive MS compared to those who started treatment later, highlighting the importance of timely intervention and MR score in treatment decisions.
Background: Acute symptomatic seizures (ASS) are a common manifestation of autoimmune encephalitis (AE), but the risk of developing epilepsy as a sequela of AE remains unknown, and factors predisposing the development of epilepsy have not been fully identified.
Objective: To assess the risk of developing epilepsy in AE and study related risk factors.
Materials And Methods: This was a retrospective single centre study including patients diagnosed with AE according to criteria described by Graus et al.