Publications by authors named "Neung S Seo"
Article Synopsis
- The dystrophin-associated protein complex (DAPC) is critical for muscle cell health and its dysfunction is linked to various muscular dystrophies.
- Researchers identified that the proteoglycan biglycan binds to the sarcoglycan subcomplex, specifically alpha- and gamma-sarcoglycan, through experiments like ligand blot overlays and co-immunoprecipitation assays.
- Studies on biglycan-deficient mice showed that the levels of alpha- and gamma-sarcoglycan were lower in young mice but remained stable in adults, indicating that biglycan may influence their expression during specific developmental stages.
Matricellular proteins such as SPARC, thrombospondin 1 and 2, and tenascin C and X subserve important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix. By virtue of its reported interaction with collagen I and deadhesive activity on cells, we hypothesized that hevin, a member of the SPARC gene family, regulates dermal extracellular matrix and collagen fibril formation. We present evidence for an altered collagen matrix and levels of the proteoglycan decorin in the normal dermis and dermal wound bed of hevin-null mice.
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