Recombinant expression and characterization of a L-amino acid oxidase from the fungus Rhizoctonia solani.

L-Amino acid oxidases (L-AAOs) catalyze the oxidative deamination of L-amino acids to the corresponding α-keto acids, ammonia, and hydrogen peroxide. L-AAOs are homodimeric enzymes with FAD as a non-covalently bound cofactor. They are of potential interest for biotechnological applications.

Assessment of hypersensitivity reactions in patients receiving carbapenem antibiotics who report a history of penicillin allergy.

Background: The use of carbapenem antibacterials in patients with a claimed history of penicillin allergy is somewhat controversial. This study aimed to examine the rates of presumed hypersensitivity reactions in a large cohort of patients receiving carbapenem antibiotics.

Methods: A retrospective chart review was performed on all adult patients who received a carbapenem in a teaching hospital from June 2011 to June 2012.

Bupropion and Citalopram in the APP23 Mouse Model of Alzheimer's Disease: A Study in a Dry-Land Maze.

Background. Incipient Alzheimer's disease is often disguised as depressive disorder. Over the course of AD, depressive symptoms are even more frequent.

Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease.

Current treatment of Alzheimer's disease rests on cholinergic and anti-glutamatergic substances. It has been suggested that acetylcholine is required for memory acquisition but is less important for memory retrieval. It was our goal to investigate the effects of treatment with donepezil, memantine, and a combination thereof on spatial memory.

[The reaction of the heart to radiation. I. State of the knowledge based on animal experimental studies].

The aim of curative tumor therapy is healing without complications. Therefore the avoidance of undesirable side-effects in healthy tissue becomes more important to such a degree as the lifespan can be prolonged by therapy: In this review the experiences to cardiac reactions by ionizing radiations are represented from experiments on animals. The former conception of a marked radioresistance of the heart has to be revised to the hitherto presented investigations.

[The reaction of the heart to radiation. II. Clinical studies].

In a review the cardiac attendant reactions in tumor irradiation in thoracal area are represented by means of papers and experiences of our own. It is shown that the heart reacts differently on ionizing rays and in special cases it can become a critical organ for radiotherapy. The diagnostic practice and the phenomenon of pericardiac and myocardiac reactions are described in detail.

[Radiation pneumonitis in the x-ray picture following megavoltage irradiation using the Neptune 10 p. linear accelerator].

For 105 patients with healthy lungs (76 breast carcinomas, 29 testicular tumors) irradiated from 1981 to 1983 with the linear accelerator Neptune 10p. the pulmonary effects of irradiation were monitored over several years. The true dose applied for breast carcinomas was 46 Gy (2 Gy per fraction), for testicular tumors 40 Gy were applied in the mediastinal field.

Remission of the newly diagnosed type 1 diabetes by radiation of the pancreas.

The process of autoaggression of the IDDM causes an "insulitis" leading to the destruction of the beta-cells. By photons (9 MV) in a total dose of 10 Gy, divided into 5 single doses at an interval of 2 days in each case we could get a total remission in 3 out of 4 diabetics, a partly remission in the fourth patient. The therapeutic effect lasts till now (1-6 months) without any further treatment.

Advances in hypoxyradiotherapy.

Observations in animal experiments and in Phase I clinical trials on the effect of breathing 8-10% oxygen are summarized. The animal tests indicated that the hypoxia induced in this way for periods varying between 10-45 minutes had a radioprotective effect on normal tissues. Patients tolerated the hypoxic treatment given for 15 minutes without any acute or late complications.

[Place of triple diagnosis in the differential diagnosis of benign and malignant breast cancers (studies of 1819 women)].

In 1819 female patients, the diagnostic value of clinical examination, mammography, and fine needle biopsy separately as well as in combination (so-called triple diagnosis) has been investigated. Comparing the histological findings with each of the several examination procedures, the triple diagnosis proved to have a high diagnostic validity (sensitivity 0.98; specificity 0.

Clinical data for radiation embryology. Investigation programme 1967, report 1984.

In 1967 a prospective clinical study was started with the aim of providing optimum counselling for married couples who desire continuation of a pregnancy despite radiation exposure at an early stage as a result of X-ray diagnostics. Recommendations were devised as to whether an interruption of pregnancy should be applied for or not. These results were discussed repeatedly.