High visual salience of alert signals can lead to a counterintuitive increase of reaction times.

It is often assumed that rendering an alert signal more salient yields faster responses to this alert. Yet, there might be a trade-off between attracting attention and distracting from task execution. Here we tested this in four behavioral experiments with eye-tracking using an abstract alert-signal paradigm.

ERP evidence for Slavic and German word stress cue sensitivity in English.

Word stress is demanding for non-native learners of English, partly because speakers from different backgrounds weight perceptual cues to stress like pitch, intensity, and duration differently. Slavic learners of English and particularly those with a fixed stress language background like Czech and Polish have been shown to be less sensitive to stress in their native and non-native languages. In contrast, German English learners are rarely discussed in a word stress context.

Development and Integration of DOPS as Formative Tests in Head and Neck Ultrasound Education: Proof of Concept Study for Exploration of Perceptions.

In Germany, progress assessments in head and neck ultrasonography training have been carried out mainly theoretically and lack standardisation. Thus, quality assurance and comparisons between certified courses from various course providers are difficult. This study aimed to develop and integrate a direct observation of procedural skills (DOPS) in head and neck ultrasound education and explore the perceptions of both participants and examiners.

New-Onset Myasthenia Gravis Confirmed by Electrodiagnostic Studies After a Third Dose of SARS-CoV-2 mRNA-1273 Vaccine.

Coronavirus disease 2019 vaccine-related pathology is a rare occurrence with few reported cases. We report on a case of a 60-yr-old man experiencing symptoms of dysphagia, dysarthria, diplopia, and weakness with onset 6 days after receiving a third full dose of SARS-CoV-2 vaccine (mRNA-1273 vaccine) in August 2021, which he received outside of the Center for Disease Control recommended guidelines, at 4 mos after his second dose of the Moderna vaccination course in March 2021. The Food and Drug Administration Emergency Use Authorization for mRNA-1273 booster was established in October 2021.

PSMA-Positive Follicular Thyroid Carcinoma Incidentally Detected by [Ga]Ga-PSMA-11 PET/CT: Correlation with Immunohistology Confirms Neovascular PSMA-Expression.

We present an interesting image of an intense PSMA-positive follicular thyroid carcinoma incidentally detected by [Ga]Ga-PSMA-11 PET/CT in a 76-year-old man with biochemical recurrence of prostate cancer. Immunohistochemical staining demonstrated PSMA expression in the endothelial cells of tumor tissue. This interesting image should remind colleagues to consider malignant thyroid neoplasia in PSMA-positive thyroid lesions.

Complete remission of an early-stage laryngeal cancer under combined pembrolizumab and chemotherapy treatment of a synchronous lung adenocarcinoma.

Background: Anti-PD1-Checkpoint inhibition (CI) is an established treatment of recurrent and/or metastatic head and neck cancer. A potential benefit from CI in early-stage disease that is usually treated by radiation or surgery has not been investigated so far and is currently not addressed in clinical trials.

Case Presentation: A 58-year-old man was diagnosed with a cT2 supraglottic laryngeal cancer and a synchronous metastasized adenocarcinoma of the lung.

Witnessing Intimate Partner Violence as a Child and Associated Consequences.

Intimate partner violence (IPV) continues to be a global problem. The increasing international research, focussing on children who witness IPV between their parents, indicates that these circumstances might influence children in different ways. Despite these efforts, little evidence stems from Germany.

Predictability-Based Source Segregation and Sensory Deviance Detection in Auditory Aging.

When multiple sound sources are present at the same time, auditory perception is often challenged with disentangling the resulting mixture and focusing attention on the target source. It has been repeatedly demonstrated that background (distractor) sound sources are easier to ignore when their spectrotemporal signature is predictable. Prior evidence suggests that this ability to exploit predictability for foreground-background segregation degrades with age.

Multi-modality bedding platform for combined imaging and irradiation of mice.

Preclinical imaging and irradiation yields valuable insights into clinically relevant research topics. While complementary imaging methods such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) can be combined within single devices, this is technically demanding and cost-intensive. Similarly, bedding and setup solutions are often specific to certain devices and research questions.

[Ultrasound-guided minimally invasive diagnostics and treatment in the head and neck area].

Tumoral lesions in the head and neck region represent a diagnostic and therapeutic challenge in otorhinolaryngologic routine. High-resolution ultrasound is usually able to guide diagnosis. Nevertheless, a definite differentiation between benign and malignant lesions can only be achieved by tissue biopsy.

The aVOR App Increases Medical Students' Competence in Treating Benign Paroxysmal Positional Vertigo (BPPV).

Hypothesis: Implementation of the "aVOR app" into teaching courses at medical school enhances students' satisfaction with the course and increases their competence in treating benign paroxysmal positional vertigo (BPPV).

Background: BPPV is often underdiagnosed and left untreated. One problem in teaching the management of BPPV to health care professionals is the lack of simulation-based training tools.

Proton radiography for inline treatment planning and positioning verification of small animals.

Introduction: As proton therapy becomes increasingly well established, there is a need for high-quality clinically relevant in vivo data to gain better insight into the radiobiological effects of proton irradiation on both healthy and tumor tissue. This requires the development of easily applicable setups that allow for efficient, fractionated, image-guided proton irradiation of small animals, the most widely used pre-clinical model.

Material And Methods: Here, a method is proposed to perform dual-energy proton radiography for inline positioning verification and treatment planning.

Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function.

Inhibitory glycine receptors containing the α3 subunit (GlyRα3) regulate sensory information processing in the CNS and retina. In previous work, we demonstrated the presence of postsynaptic GlyRα3 immunoreactivity at efferent synapses of the medial and lateral olivocochlear bundle in the organ of Corti; however, the role of these α3-GlyRs in auditory signalling has remained elusive. The present study analyzes distortion-product otoacoustic emissions (DPOAEs) and auditory brainstem responses (ABRs) of knockout mice with a targeted inactivation of the Glra3 gene (Glra3(-/-)) and their wildtype littermates (Glra3(+/+)) before and seven days after acoustic trauma (AT; 4-16 kHz, 120 dB SPL, 1 h).

The endoplasmic reticulum is the main membrane source for biogenesis of the lytic vacuole in Arabidopsis.

Vacuoles are multifunctional organelles essential for the sessile lifestyle of plants. Despite their central functions in cell growth, storage, and detoxification, knowledge about mechanisms underlying their biogenesis and associated protein trafficking pathways remains limited. Here, we show that in meristematic cells of the Arabidopsis thaliana root, biogenesis of vacuoles as well as the trafficking of sterols and of two major tonoplast proteins, the vacuolar H(+)-pyrophosphatase and the vacuolar H(+)-adenosinetriphosphatase, occurs independently of endoplasmic reticulum (ER)-Golgi and post-Golgi trafficking.

Arabidopsis has two functional orthologs of the yeast V-ATPase assembly factor Vma21p.

How individual protein subunits assemble into the higher order structure of a protein complex is not well understood. Four proteins dedicated to the assembly of the V(0) subcomplex of the V-adenosine triphosphatase (V-ATPase) in the endoplasmic reticulum (ER) have been identified in yeast, but their precise mode of molecular action remains to be identified. In contrast to the highly conserved subunits of the V-ATPase, orthologs of the yeast assembly factors are not easily identified based on sequence similarity.

Socioecological aspects of human reproduction in Sub-Saharan Africa.

The purpose of this study was to compare fertility outcome of two populations of northern Namibia, following different ways of subsistence. The total number of offspring, but also the number of dead and surviving offspring was compared between 236 !Kung San (91 females, 145 males) hunter gatherers and 248 Kavango (87 females, 161 males) horticultural pastoralists and a small number of Kavango people living in the urban center of Rundu. While no typical differences in fertility outcome between the study populations could be observed in males, marked differences were found for the female sample.

Plasma levels and cardiovascular gene expression of urotensin-II in human heart failure.

The peptide urotensin-II (U-II) has been described as most potent vasoconstrictor identified so far, but plasma values in humans and its role in cardiovascular pathophysiology are unknown. We investigated circulating urotensin-II and its potential role in human congestive heart failure (CHF). We enrolled control individuals (n=13; cardiac index [CI], 3.

[Approaches to the determination of social anthropologic status in Austria].

The variation of height and psychological test results based on the data of 22,872 Austrian conscripts (year of birth: 1964) was analysed, considering urban-rural and differences in occupation. The observed results are in accordance with the hitherto reported observations. It is seen that the social differences in body height are decreasing, whereas the social differences in intellectual capacities seem to increase.

[Treatment and results in malleolar fractures].

The authors compared the therapy results of 100 conservatively treated malleolar fractures and 100 malleolar fractures operated upon with the therapy results of the malleolar fractures registered at the documentation centre of the A. O. (working association for osteosynthesis) in Bern.

[Results of surgical treatment of recent capsular ligament lesions of the knee joint (author's transl)].

During the period from 1971 to spring 1981, 85 patients with recent ruptures of the knee ligament were operated at the Hospital of Accident Surgery of Giessen. After 38.3 months on an average, 55 patients could be submitted to a follow-up examination.

[Investigation about the stability of a fixateur-externe using a new screw nail (author's transl)].

Since former investigations showed that the 4.5 mm Steinmann-nails hitherto were the weakest part of fixateur-externe systems, we developed a screw nail with a shank thickness of 7 mm and a thread identical to that of the cortical screw developed by the Arbeitsgemeinschaft für Osteosynthese (Workshop Society for Osteosynthesis). By conducting experiments with a metal alloy (square tube made of aluminium) in cadaver bones, the bending stress of a frame assembly R and of a three-dimensional assembly with 2 Schanz-screws Z2S was examined with 4.

[Analysis of the therapeutic results in 1127 patients with fractures of the femur in the Federal Republic of Germany and in Switzerland (author's transl)].

Under the aspect of quality control of the surgical treatment the results of femur-fractures of 1127 patients were scrutinized. These patients were treated in 16 German and in 21 Swiss AO-hospitals. Different complications are discussed.