Regulation of Peptide Liquid-Liquid Phase Separation by Aromatic Amino Acid Composition.

Membraneless organelles are cellular biomolecular condensates that are formed by liquid-liquid phase separation (LLPS) of proteins and nucleic acids. LLPS is driven by multiple weak attractive forces, including intermolecular interactions mediated by aromatic amino acids. Considering the contribution of π-electron bearing side chains to protein-RNA LLPS, systematically study sought to how the composition of aromatic amino acids affects the formation of heterotypic condensates and their physical properties.

Emergent properties of melanin-inspired peptide/RNA condensates.

Most biocatalytic processes in eukaryotic cells are regulated by subcellular microenvironments such as membrane-bound or membraneless organelles. These natural compartmentalization systems have inspired the design of synthetic compartments composed of a variety of building blocks. Recently, the emerging field of liquid-liquid phase separation has facilitated the design of biomolecular condensates composed of proteins and nucleic acids, with controllable properties including polarity, diffusivity, surface tension, and encapsulation efficiency.

[DR. ARIEH LEIB SHIMONI-MEKLER - EYE, EAR, NOSE AND THROAT SPECIALIST].

Although the inauguration of the new hospital in Zefat built by Baron Rothschild took place in 1910, the building was not used as a hospital until World War I when it was confiscated by the Turks for patients affected with typhus, and later it was converted into a military hospital. The second inauguration of the renewed hospital was in June 1919, and the medical activity was assigned to the American Zionist Medical Unit for Palestine' (AZMU), later - 'Hadassah Medical Organization'. Among the first doctors that were sent to Zefat by AZMU was Dr.

Opiate Analgesics and the Perioperative Management of Patients with Obstructive Sleep Apnea.

As the rate of obesity and subsequently obstructive sleep apnea (OSA) continue to rise in North America and prescriptions for narcotic analgesics number in the tens of millions, it has become increasingly important to understand the interaction between OSA and opiate analgesics. Understanding the mechanism of action of opiate analgesics and the pathophysiology of OSA can help medical professionals understand the unique risks associated with pain management in this population of patients.

Long-term outcome of patients with antiphospholipid syndrome who undergo percutaneous coronary intervention.

Objectives: Patients with antiphospholipid antibody syndrome (APS) have an increased risk of atherothrombotic complications. There are limited data regarding the outcome of patients with APS who undergo percutaneous coronary intervention (PCI). Accordingly, we aimed to assess the long-term outcomes of these patients.

[Dr. Moshe Sherman--the first otolaryngologist in Eretz-Israel: 100 years since his arrival].

On 4.8.1911 Dr.

[A prophet without honor in his own country: Dr. Ernst Wodak (1891-1962)].

Among all otolaryngologists who lived in Israel during the first half of the 20th century, one was most prominent - Dr. Ernst Wodak. Ernst Wodak was born in Czechoslovakia in 1891 and he graduated from the German University of Prague in 1915.

Implanted upper airway stimulation device for obstructive sleep apnea.

Objectives/hypothesis: Previous feasibility studies have shown that electrical stimulation of the hypoglossal nerve can improve obstructive sleep apnea (OSA). The current study examined the safety and preliminary effectiveness of a second generation device, the Upper Airway Stimulation (UAS) system, and identified baseline predictors for therapy success.

Study Design: Two consecutive open prospective studies.

Clopidogrel tapering as a strategy to attenuate platelet rebound phenomenon in patients with bare-metal stents.

Early clustering of adverse cardiovascular events after abrupt cessation of clopidogrel has been reported in patients with acute coronary syndromes. A platelet rebound phenomenon may contribute to this increased thrombotic risk and a gradual drug tapering may attenuate this proposed platelet effect. Accordingly, we aimed to assess the effect of clopidogrel tapering on platelet reactivity.

Vascular injury following accidental intra-arterial injection of clindamycin: adverse drug reaction report.

Clindamycin in a commonly used antibiotic, considered safe for oral, intravenous and intra-arterial use. We present a case of a patient that received an inadvertent injection clindamycin 600 mg in 4 mL through a radial arterial line. The patient presented signs and symptoms of vascular occlusion and despite aggressive pharmacological and medical treatment developed massive and severe tissue injury.

Abrupt tonsillar hemorrhage from a metastatic hemangiosarcoma of the breast: case report and literature review.

We describe a case of primary breast hemangiosarcoma with tonsillar metastasis that manifested as a profuse oropharyngeal hemorrhage. The patient was a 54-year-old woman who presented to the emergency department with oral bleeding. A thorough examination revealed a distorted morphology of the left tonsil and a hemorrhage originating from it.

Parameters affecting pharyngeal response to genioglossus stimulation in sleep apnoea.

Chronic stimulation of the hypoglossus nerve may provide a new treatment modality for obstructive sleep apnoea (OSA). In previous studies we observed large differences in response to stimulation of the genioglossus (GG). We hypothesised that both individual patient characteristics and the area of the GG stimulated are responsible for these differences.

Protection of high-riding aberrant innominate artery during open tracheotomy.

Purpose: Variations of the normal anatomy of the aortic great vessels can lead to severe complications if not recognised pre- or peri-operatively. One such anomaly is a high-riding aberrant innominate artery.

Study Design: Retrospective review of case series.

[Frontal sinus fractures: five years of treatment experience].

Background: Frontal sinus fractures are commonly encountered in major trauma centers. They are almost exclusively seen in young adults and are usually caused by high velocity impacts. The intimate association of the frontal sinuses with structures such as frontal lobes and the eyes makes the appropriate management of this injury essential.

Safe extraction of an impacted open safety pin from the esophagus: report of 9 cases.

Purpose: Foreign body ingestion is a common problem in children. An infrequent ingested item is an open safety pin (SP), which may become lodged in the esophagus and presents the endoscopist a challenge to his surgical judgment and technical skills.

Materials And Methods: We present 9 cases of infants with open SPs impacted in the esophagus and discuss the different options to treat these cases.

[Safe extraction of an impacted open safety pin from the esophagus: a new technique and five case studies].

Esophageal foreign bodies are common, especially in children less than 5 years old. However, the presence of an open safety pin in the esophagus is quite rare. When this occurs, immediate removal of the safety pin is recommended due to its propensity to pierce the esophagus and surrounding structures causing severe and sometimes even lethal complications.

Does otitis media in early childhood affect reading performance in later school years?

Objective: To evaluate reading performance in children with recurrent otitis media during childhood once middle-ear diseases have resolved and the children grew older.

Study Design And Setting: Seventy-five children with middle-ear problems during childhood and poor reading performance in first grades and 60 healthy controls free of middle ear diseases were enrolled in the study. All children underwent an otologic and audiologic evaluation followed by reading tests.

Percutaneous tracheotomy in bone marrow transplant patients with severe thrombocytopenia.

Objective: Evaluation of percutaneous tracheotomy in bone marrow transplant patients with severe thrombocytopenia.

Design: A retrospective outcome study.

Patients: A retrospective study of 26 percutaneous tracheotomies was performed at the Bone Marrow Transplant Unit, Rambam Medical Center, Haifa, Israel.

Reading performance in children with otitis media.

Objective: To examine whether middle ear diseases and the associated hearing loss in early childhood affect reading performance later at school.

Study Design And Setting: One hundred and sixty children, 6.5 to 8 years of age, were enrolled in this study: 80 children with a history of recurrent infections and/or prolonged periods of effusions of the middle ear before the age of 5 years, and 80 healthy children without any history of middle ear disease.

Delayed diagnosis of tracheoesophageal prosthesis aspiration.

In 1980, Singer and Blom published the results of their study on use of the tracheoesophageal puncture prosthesis for restoration of voice after total laryngectomy. Since then, the placement of tracheoesophageal puncture prostheses has been an integral part of rehabilitation after laryngectomy. Complications of this procedure have been recognized and are usually minimal.

Bilateral tinnitus due to middle-ear myoclonus.

Tinnitus is a common otological symptom. Usually it is subjective (perceived only by the patient); very rarely is it objective (heard by both the patient and the examiner) Objective tinnitus due to middle-ear myoclonus is extremely rare, with only a few case reports published in the literature. We present three cases of objective tinnitus caused by middle-ear myoclonus.

Extension of nasopharyngeal lymphoma to the middle and external ear.

We describe a patient with nasopharyngeal lymphoma who was admitted for chemotherapy. At admission, otoscopic examination revealed a large polyp occluding the left external ear canal. The polyp was removed, and histopathologic examination showed the same tumor that was found previously in the nasopharynx.

Antioxidants in treatment of idiopathic sudden hearing loss.

Objective: Assuming that superoxide anion radicals (O(2)-) may play a role in damage to the inner ear, the authors investigated the possible benefit of vitamin E as an antioxidant in the treatment of idiopathic sudden hearing loss.

Study Design: Prospective, double-blind study.

Setting: The Department of Otolaryngology of Rambam Medical Center serves as a tertiary referral center for a population of 1.