Enriching the drinking water of rats with extracts of Salvia officinalis and Thymus vulgaris increases their resistance to oxidative stress.

Nature is an attractive source of therapeutic compounds. In comparison to the artificial drugs, natural compounds cause less adverse side effects and are suitable for current molecularly oriented approaches to drug development and their mutual combining. Medicinal plants represent one of the most available remedy against various diseases.

HPLC determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human serum of oncological patients after administration of morphine drugs.

A simultaneous determination of morphine (M) and its two metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), by HPLC in the serum of oncological patients is described. The compounds are extracted from the serum by means of Chromabond C18--EC solid-phase-extraction cartridges, separated on a Symmetry C18 analytical column (150 x 4.9 mm, 5 microm) and detected by a UV detector at 210 nm.

Spectrofluorimetric determination of fendiline in tablets.

A simple, sensitive and accurate spectrofluorimetric method was developed for the assay of fendiline in tablets. Validation of the method provided good results concerning linearity, precision and accuracy. The linearity range was found to be 0.

Rapid HPLC analysis of melphalan applied to hyperthermic isolation limb perfusion.

Hyperthermic isolated limb perfusion (HILP) with melphalan (MH) as a standard cytotoxic drug has been performed in 28 patients suffering from malignant melanoma. MH has been administered by HILP via extracorporeal circulation system. The drug given locoregionally reduces subsequent toxicity of organs.

Do vancomycin serum levels predict failures of vancomycin therapy or nephrotoxicity in cancer patients?

The purpose of this study was to determine if patients with high vancomycin (VAN) serum levels experience more toxicity than underdosed patients with lower (VAN) levels, and whether low VAN serum levels cause therapeutic failures in patients with gram-positive bacteremia. In 198 cancer patients trough and peak serum levels of VAN were measured. Acute toxicity (Red Man syndrome) appeared in 3 patients (1.

Do low vancomycine serum levels predict failures of vancomycine therapy in neutropenic cancer patients?

Vancomycine serum levels were measured in 198 cancer patients with documented grampositive bacteremia and twenty two failed. Failures were analyzed for risk factors of therapy failure. Only 8 of 22 showed low serum peak or through vancomycin levels.

[Determination of serum vancomycin using capillary isotachophoresis].

The paper aims to study the possibilities of determining vancomycin in the serum by the method of capillary isotachophoresis. The leading electrolyte contained Na+ as the leading ion, morpholinoethanesulphonic acid as the counter-ion (pH 6,2), and methylhydroxyethyl cellulose as the additive. The terminating electrolyte was morpholinoethanesulphonic acid.

Quantitative assay of verapamil in drugs and serum by capillary isotachophoresis.

Experimental conditions for a simple capillary isotachophoresis (ITP) with conductometric detection have been created for the determination of verapamil in drugs and serum. The limit of detection (LD) was 80 ng.cm-3 for standard verapamil solution.