Publications by authors named "Netricia Govender"
Universal drug susceptibility testing (DST) is an important requirement of the End TB Strategy. The Sensititre broth micro-dilution assay (BMD) tests multiple drugs quantitatively. We defined interpretive criteria for this assay and analysed genotypic-phenotypic relationships.
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- Bedaquiline (BDQ) is a new drug approved for treating multi-drug resistant tuberculosis (MDR-TB), and this study aimed to establish threshold values for BDQ effectiveness, assess its resistance patterns, and evaluate its relationship with another drug, clofazimine (CFZ).
- The research involved analyzing 391 tuberculosis samples to determine susceptibility levels, with specific minimum inhibitory concentrations (MICs) indicating resistant, intermediate, and susceptible categories for BDQ and CFZ.
- Findings showed that patients with specific genetic mutations (Rv0678) and non-susceptible BDQ levels faced higher treatment failures, highlighting the need for improved testing methods to detect BDQ resistance, while emphasizing that cross-resistance with