Publications by authors named "Nestor Herrera-Chavez"
Genomic and Phylogenomic Characterization of Carbapenem-resistant Pseudomonas aeruginosa 'High-risk' Clone O4/ExoS+/ST654 Circulating in Chilean Hospitals.
Andrés Opazo-Capurro Omar Alejandro Aguilar-Vera Paulina González-Muñoz Luis Amsteins-Romero Monserrat Quiroga
J Glob Antimicrob Resist
September 2024
Article Synopsis
- Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a major public health concern in Chile, mainly linked to ventilator-associated pneumonia, with limited molecular epidemiological data available.
- A study characterized the phylogenomics and molecular characteristics of ST654 CRPA isolates collected between 2016 and 2022, involving 89 samples from various hospitals.
- Results showed that 38.2% of the strains belonged to the high-risk ST654 clone, primarily associated with KPC production, a broad resistome, and specific virulence factors, highlighting the need for ongoing molecular surveillance.
The emergence of community-acquired methicillin-resistant (CA-MRSA) infections at the end of the 20th century represents a significant shift in the epidemiology of staphylococcal infections and, consequently, their clinical management. There are diverse CA-MRSA clones that are widely spread worldwide, showing differences in their regional dissemination, which has been dynamically changing over time. Although the first CA-MRSA description occurred about 30 years ago, its epidemiology in certain regions, such as South America, has been poorly explored, resulting in a gap in the understanding of the epidemiology of CA-MRSA in under-represented countries/regions.
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