Synthesized zinc peroxide nanoparticles (ZnO-NPs): a novel antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory approach toward polymicrobial burn wounds.

Increasing of multidrug resistance (MDR) remains an intractable challenge for burn patients. Innovative nanomaterials are also in high demand for the development of new antimicrobial biomaterials that inevitably have opened new therapeutic horizons in medical approaches and lead to many efforts for synthesizing new metal oxide nanoparticles (NPs) for better control of the MDR associated with the polymicrobial burn wounds. Recently, it seems that metal oxides can truly be considered as highly efficient inorganic agents with antimicrobial properties.

Efficacy of Pluchea dioscoridis leaf extract against pathogenic Candida albicans.

Introduction: This study aimed to evaluate the efficacy of Pluchea dioscoridis leaf extract on growth, survival, morphogenesis, and virulence gene expression of Candida albicans.

Methodology: Anticandidal activity was studied using the hole-plate method against four pathogenic C. albicans strains from clinical isolates.

Anti-proteolytic activity of Ganoderma lucidum methanol extract against Pseudomonas aeruginosa.

Introduction: Protease enzyme is considered one of the most serious virulence factors produced by extended-spectrum β-lactamase-producing and multidrug-resistant Pseudomonas aeruginosa (ESβLMDRPA) clinical isolates.

Methodology: The antibacterial activity of methanol extract of Ganoderma lucidum fruiting bodies was tested against a protease-producing ESβLMDRPA clinical isolate, showing its mode of action.

Results: The extract showed high antibacterial activity.