Publications by authors named "Nesrine Salem"

The evaluation of sperm DNA integrity is recommended in the sixth edition of the 2021 World Health Organization guidelines. Oxidative stress has been identified as a crucial factor leading to genome decay, lipid peroxidation, and nucleoprotein oxidation. This double-blind, placebo-controlled clinical trial aimed to assess the effect of oral antioxidant treatment (Fertilis), which contains L-carnitine and some micronutrients, in the improvement of conventional sperm parameters, sperm DNA integrity and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes.

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Article Synopsis
  • Alzheimer's disease (AD) is a major global health issue, and this study investigates the role of mitochondrial DNA in relation to its onset, specifically within the Tunisian population.
  • Researchers analyzed 159 single-nucleotide polymorphisms (SNPs) from mitochondrial DNA in 254 individuals, alongside assessing the presence of the APOE ε4 gene, known to increase AD risk.
  • The study found no significant link between mitochondrial haplogroups and AD, but discovered two specific SNPs that were associated with the disease, while confirming APOE ε4 as a significant risk factor.
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The COMT gene encodes for catechol-O-methyl-transferase, an enzyme playing a major role in regulation of synaptic catecholamine neurotransmitters. Investigating 4 markers of the COMT gene (rs2020917, rs4818, rs4680, rs9332377) in 6 Tunisian populations and a pool of Libyans. Our objective was to determine the distribution of allelic, genotypic and haplotypic frequencies by comparison to other populations of the 1000 genomes project and 59 populations from the Kidd Lab dataset.

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Methylprednisolone (MP) is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury (SCI). Vitamin C (VC) is a natural water-soluble antioxidant that exerts neuroprotective effects through eliminating free radical damage to nerve cells. Bone marrow mesenchymal stem cells (BMMSCs), as multipotent stem cells, are promising candidates in SCI repair.

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