Insecticidal efficacy of afoxolaner against (Diptera: Muscidae) in dogs.

The insecticidal activity of oral afoxolaner (NexGard®) against stable flies (Diptera: Muscidae) that had fed on dogs was evaluated in a blinded, randomised, and negative controlled efficacy study. The efficacy assessments were based on survival rates of fed flies after challenges to treated dogs. For a challenge, each dog was exposed to 50 unfed for 30 minutes, after which time live fed flies were collected and incubated in an insectarium for viability assessment after 48, 72 and 96 hours.

Insecticidal efficacy of afoxolaner against bedbugs, Cimex lectularius, when administered orally to dogs.

The objective of this experimental study was to assess the insecticidal efficacy of afoxolaner (NexGard) against bedbugs (Cimex lectularius) on dogs. For each challenge, 20 bedbugs were placed in two chambers positioned in contact to the dog's skin for 15 min, after which live fed parasites were counted and incubated for survival evaluations. On Day 0, 7 dogs assigned to the treated group were administered afoxolaner orally at the registered dose.

Assessment of the insecticidal activity of oral afoxolaner against Phlebotomus perniciosus in dogs.

Twelve healthy dogs were included in this laboratory efficacy study. Six dogs were randomly allocated based on body weight to an untreated control group and six to an afoxolaner (NexGard) treated group. In the treatment group, afoxolaner was administered orally on Day 0 in accordance with label instructions.