Publications by authors named "Nesrine A Mohamed"

Pollen is well known to cause seasonal allergy. Ragweed sensitization and allergy represent a worldwide challenge for allergists. Ambrosia is one of the major genera in the Asteraceae family which includes at least 51 species known as "ragweed".

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Article Synopsis
  • Chronic spontaneous urticaria (CSU) is a common skin condition affecting many people, with around 90% of cases being idiopathic, and nearly half thought to involve autoimmune mechanisms.
  • The study examined the presence of specific T regulatory cells (CD4+CD25highFOXP3+) in CSU patients and their link to autologous serum skin tests (ASST).
  • Results showed that CSU patients had lower levels of these T regulatory cells compared to healthy individuals, supporting the idea that CSU is related to immune system issues and suggesting potential avenues for new treatments.
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Background: Glucocorticoid (GC)-resistant asthma, a complex disease phenotype, has a high morbidity and mortality and takes up a disproportionate share of healthcare costs. The aim of this work was to assess serum 25-hydroxyvitamin D (25(OH)VD) levels in steroid-resistant, steroid-sensitive patients with asthma and in healthy controls, and to investigate the association between the vitamin D receptor gene (VDR) FokI and ApaI polymorphisms and GC resistance in patients with asthma.

Methods: This case-control study included 70 patients with severe bronchial asthma and 30 apparently healthy controls.

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Background: Well-known allergy tests are used to evaluate and diagnose allergic diseases. The aim of this study was to assess the role of serum level diamine oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy.

Methods: This case-control study included 40 patients with respiratory allergies (atopic asthma and allergic rhinitis) as well as 40 age- and sex-matched controls.

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Cow's milk allergy (CMA) is known to be either IgE- or non-IgE mediated. Regulatory T (Treg) cell defect is involved in the pathogenesis of both types. Vitamin D has been suggested to improve the generation of allergen-specific Treg cell populations with the potential to provide safe and long-term alleviation of disease symptoms.

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This study aimed to determine whether plasma soluble urokinase plasminogen activator receptor (suPAR) could serve as an activity biomarker in systemic lupus erythematosus (SLE) patients. suPAR levels were assessed in SLE patients, compared to healthy controls and correlated with disease activity. Sixty SLE patients were enrolled with assessment of disease activity using SLE Disease Activity Index (SLEDAI), C3, soluble urokinase plasminogen activator receptor level.

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Background: Zinc deficiency may play an important role in the development of atopic asthma.

The Aim Of The Work: To assess serum zinc levels in adult atopic, non-atopic asthmatic patients, and in healthy controls and to investigate its modulatory effect on production of interferon gamma (IFN-γ) and interleukin-10 (IL-10) by peripheral blood mononuclear cells (PBMCs) in vitro.

Methods: Sixty asthmatics and 30 apparently healthy volunteers were included in this study.

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Introduction: Tuberculosis (TB) remains a huge worldwide burden, despite extensive vaccination coverage with the Bacillus Calmette-Guérin (BCG), the only vaccine available against this disease, indicating that BCG-driven immunity is inadequate to protect the human population against TB. This underscore the critical necessitate to develop an improved TB vaccine, based on a better understanding of host-pathogen interactions and immune responses during mycobacterial infection.

Aim Of The Work: To examine whether the exogenous addition of IFN-β could improve dendritic cell (DC) response to Mycobacterium bovis (M.

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Aim: To identify the prevalence and effect of hepatopathies of different etiologies among pediatric patients with type 1 diabetes mellitus (T1DM) using transient elastography (TE) and its relation to glycemic control.

Methods: One hundred T1DM patients were studied focusing on liver functions, fasting lipid profile, hemoglobin A1c (HbA1c), hepatitis C virus (HCV), serum immunoglobulins, autoimmune antibodies; anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA), and anti-liver kidney microsomal antibody (anti-LKM). Abdominal ultrasound was performed and TE was done for patients with HCV, positive autoimmune antibody and/or abnormal ultrasound findings.

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Article Synopsis
  • The study investigates the link between a specific genetic variation (NR3C1 646 C>G) and severe bronchial asthma, focusing on how it may contribute to resistance against glucocorticoids.
  • It involved 40 patients with severe asthma and 20 healthy individuals, assessing their atopic status and conducting tests to determine their responsiveness to glucocorticoids.
  • Results indicated that certain genotypes (CC) were more common among asthma patients and those who are sensitive to glucocorticoids, suggesting a potential genetic factor in asthma severity and treatment response, but larger studies are needed for conclusive results.
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Background: Allergic rhinitis occurs on exposure to a known allergen and is correlated with a positive skin test and physical examination results. Tryptophan is a substrate of many important proteins, e.g.

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Introduction: Dendritic cells (DCs) are the most efficient antigen presenting cells, which are considered a central component of the immune system for their extraordinary capacity to initiate and modulate the immune responses elicited upon recognition of infectious agents. This has made them a major focus of interest in the conception of immunotherapeutic vaccine strategies.

Aim Of The Study: To standardise a protocol for in vitro differentiation of human peripheral blood monocytes into immature DCs (iDCs) upon treatment with specific growth factors and to compare two monocyte isolation methods including magnetic activated cell sorted (MACS) monocytes by CD14(+) immuno-magnetic beads and monocytes separated by adherence.

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Objective: We aimed to assess the percentage of peripheral blood B-lymphocytes expressing OX40 ligand (OX40L) in adult atopic and non-atopic asthmatic patients, and in healthy controls.

Methods: This case-control study included 15 atopic asthmatic patients, 15 non-atopic asthmatic patients, and 15 healthy controls. Atopic status was determined by skin prick test reaction to the most common locally-encountered allergens.

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Vitamin D has an important role in the immune system. Decreased serum vitamin D level is known to be associated with autoimmune and atopic diseases. This study aimed to assess vitamin D status in patients with chronic spontaneous urticaria (CSU) and its relation with severity of the disease.

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Resistin and visfatin have been proposed as playing a role in the pathogenesis of insulin resistance. We assessed the relationship between their serum concentrations and insulin resistance in lean, obese diabetic and obese non-diabetic. We explore their relationship with inflammatory markers and anthropometric parameters in obese patients.

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The concept that regulatory T cells (Treg) play a key role in both development and maintenance of autoimmune response in rheumatological diseases is well accepted. In recent years, several studies analyzed Treg cell phenotype and function in systemic lupus erythematosus (SLE), the prototypical systemic autoimmune disorder in humans. The forkhead family transcription factor FOXP3 currently represents the most specific marker molecule for T cells with suppressive/regulatory capacity (Treg).

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