Publications by authors named "Nesma A Shiha"
Article Synopsis
- Depression is a significant global health issue that often leads to economic challenges, and traditional antidepressants frequently cause side effects that hinder patient adherence to treatment.
- This study evaluated the effects of trimetazidine (TMZ), an anti-ischemic drug, on depression in a mouse model, focusing on its influence on key signaling pathways linked to inflammation and oxidative stress.
- The findings indicated that TMZ reduced signs of despair in treated mice, improved neuronal health, and showed potential as a new treatment option for depression by modulating specific biological pathways, necessitating further studies in humans.
Unlabelled: Depression is a serious mood disorder characterized by monoamines deficiency, oxidative stress, neuroinflammation, and cell death. Niacin (vitamin B3 or nicotinic acid, NA), a chief mediator of neuronal development and survival in the central nervous system, exerts neuroprotective effects in several experimental models.
Aims: This study aimed to investigate the effect of NA in lipopolysaccharide (LPS) mouse model of depression exploring its ability to regulate sirtuin1/poly (ADP-ribose) polymerase-1 (PARP-1)/nod-likereceptor protein 3 (NLRP3) signaling.
Type 2 diabetes mellitus (T2DM) has been recognized as a known risk factor for cardiovascular diseases. Additionally, studies have shown the prevalence of depression among people with diabetes. Thus, the current study aimed to investigate the possible beneficial effects of escitalopram, a selective serotonin reuptake inhibitor, on metabolic changes and cardiac complications in type 2 diabetic rats.
View Article and Find Full Text PDFBackground: Endotoxin-induced neuroinflammation plays a crucial role in the pathogenesis and progression of various neurodegenerative diseases. A growing body of evidence supports that incretin-acting drugs possess various neuroprotective effects that can improve learning and memory impairments in Alzheimer's disease models. Thus, the present study aimed to investigate whether alogliptin, a dipeptidyl peptidase-4 inhibitor, has neuroprotective effects against lipopolysaccharide (LPS)-induced neuroinflammation and cognitive impairment in mice as well as the potential mechanisms underlying these effects.
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