Publications by authors named "Nese Ozbey"
Article Synopsis
- Thyroid cancer associated with ovarian teratoma is rare, as shown in a case of a 26-year-old woman who had a follicular variant papillary thyroid carcinoma found during surgery for cystic ovarian masses.
- After surgery, her tumor markers returned to normal, but follow-up imaging revealed cystic masses in her abdomen.
- Total thyroidectomy and I-131 treatment were successful in eradicating the cancer, and it is suggested that such cases be approached similarly to primary thyroid cancers, combining radical surgery as necessary, with an option for fertility-preserving procedures.
Article Synopsis
- During pregnancy, women experience increased serum triglyceride (TG) and cholesterol levels, which can be dangerous for those with genetic hypertriglyceridemia, potentially leading to serious conditions like pancreatitis.
- The study involved two pregnant women with severe hypertriglyceridemia; therapeutic apheresis was used alongside medical nutrition therapy and ω-3 fatty acids to manage their conditions.
- Results showed that while double filtration apheresis reduced TG levels by up to 46.3%, plasmapheresis was more effective, achieving a 72% reduction, ultimately confirming that therapeutic apheresis can effectively manage dangerously high TG levels during pregnancy.
Article Synopsis
- The study investigated how thyroid removal affects certain fat-related hormone levels (leptin, adiponectin, and resistin) in women with hypothyroidism.
- Thirty premenopausal women undergoing thyroidectomy were analyzed for changes in hormone levels and body measurements before and after surgery.
- Although participants experienced significant weight gain and increased body fat after surgery, their levels of the hormones studied did not show significant changes related to their thyroid hormone levels.
Introduction: Autopsy series have shown that metastasis to the thyroid gland has occurred in up to 24% of patients who have died of cancer. Neuroendocrine tumors may metastasize to thyroid gland.
Case Presentations: Case 1 was a 17-year-old Turkish woman who was referred from our Endocrinology Department for a thyroidectomy for treatment of neuroendocrine tumor metastasis.
Article Synopsis
- In papillary thyroid carcinoma (PTC), although many patients have a seemingly good prognosis after initial treatment, recurrences can still occur, especially during long-term follow-up.
- A study evaluated 469 patients classified as low-risk 9 to 12 months post-treatment and found that factors such as larger tumor size, higher stimulated thyroglobulin (STg) levels, and positive anti-thyroglobulin antibodies were linked to a higher chance of recurrence.
- Of the patients, only 2.6% experienced recurrences, but those with positive anti-Tg tests had a significantly higher recurrence rate compared to those who tested negative.
The aim was to evaluate the concentrations of lipid subfractions in relation to adipokines and metabolic parameters in adult growth hormone (GH)-deficient hypopituitary patients on conventional replacement therapy. The study included 21 GH deficient-hypopituitary patients (age: 36.0 ± 15.
View Article and Find Full Text PDFBackground: The etiology of postoperative hypocalcemia after total thyroidectomy appears to be multifactorial, that is, postoperative transient hypoparathyroidism, low 25-hydroxy vitamin D (25-OHD) concentrations, aging, and hyperthyroidism with increased bone turnover. Our aim was to evaluate the factors responsible for postoperative hypocalcemia in euthyroid vitamin D-deficient/insufficient Graves patients who underwent total thyroidectomy at our institution.
Methods: Thirty-five consecutive patients with Graves disease treated by total thyroidectomy were included in the present study.
Objective: Fibroblast growth factor 23 (FGF23), a phosphatonin, inhibits renal phosphate reabsorption and suppresses 1-α hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women and to compare the FGF23 concentrations of vitamin D-deficient patients with healthy subjects and patients with genetically determined hypophosphatemic rachitis.
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- Transient pregnancy-induced Cushing's syndrome (CS) is a rare condition linked to ectopic LH/hCG-receptors in the adrenal gland, affecting a 29-year-old woman who experienced repeated miscarriages during multiple pregnancies.
- The patient's signs of hypercortisolism improved post-delivery or abortion but recurred in subsequent pregnancies; tests showed elevated cortisol levels that didn't suppress with dexamethasone.
- Molecular analysis indicated a significant increase in LHCGR and hormonal receptor expression in her adrenal tissue, suggesting a germline duplication of the LHCGR gene as a potential cause of her condition.
Background: It is not clear whether nonfunctional adrenal incidentaloma (NFA) increases the risk of atherosclerosis and metabolic syndrome or whether this type of adrenal tumor has been found more frequently in patients with cardiometabolic risk factors. We aimed to determine the effects of NFA on cardiometabolic risk factors and endothelial function and to compare the patients with a 1:1 cardiometabolic risk factor matched control group.
Methods: Thirty-five patients with NFA were studied, and 35 body mass index-, age-, and sex-matched subjects were regarded as group 2 controls.
Background: Incidental resection of parathyroid tissue is not uncommon during thyroidectomy and may occur even in the hands of experienced thyroid surgeons. We aimed to investigate the clinical relevance of incidental parathyroidectomy and to determine which risk factors are important for it.
Patients: Four hundred and forty consecutive patients with non-toxic multinodular goitre treated by total and near-total thyroidectomy were included prospectively in the present study.
Context: Data regarding serum adipocytokine and ghrelin concentrations in different stages of anorexia nervosa (AN) is conflicting.
Objective: Our aim is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of AN and to evaluate their relationships with study parameters.
Design Setting And Participants: Study group was composed of four subgroups: Group 1: patients with a recent diagnosis of AN (n = 19); group 2: weight recovered (10% increase in body weight compared with baseline) subgroup of group 1 during follow-up (n = 10); group 3: recovered patients with a previous history of AN but normal menstrual cycles and body weight currently (n = 10); group 4: control group (n = 10).
Objective: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients.
View Article and Find Full Text PDFBackground/aims: Overt and subclinical hypothyroidism are reported to be associated with increased cardiovascular disease risk. We have used coronary flow reserve (CFR) measurement by trans-thoracic Doppler echocardiography (TTDE) to determine coronary microvascular function in Hashimoto's thyroiditis patients with overt and subclinical hypothyroidism and to evaluate effects of L-thyroxine replacement on coronary endothelial function.
Methods: In total, 10 overt hypothyroid patients, 10 subclinical hypothyroid patients, and 10 controls were enrolled.
Hypothesis: Age, postoperative serum parathormone (PTH) level, and preoperative serum 25-hydroxyvitamin D(3) (25-OHD) level predict postoperative hypocalcemia after total thyroidectomy.
Design: Prospective clinical trial.
Setting: Tertiary referral center.
Objective: To describe and discuss potential relationships between anorexia nervosa (AN) and Raynaud's phenomenon, the course and concurrent treatment of these two disorders as they appeared simultaneously, and a potential treatment modification entailed in such concurrent therapies.
Background: Although Raynaud's phenomenon has been described during the course of AN, the associations and interactions between these two conditions are not clear.
Method: We report the medical workup, treatment, and outcomes in a 19-year old female patient who developed Raynaud's phenomenon following the onset of AN.
Objective: Relationship between adult growth hormone deficiency (AGHD) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (GH) administration. Endothelial dysfunction, an early and reversible event in pathogenesis of atherosclerosis, is associated with increased vascular smooth muscle tone, arterial stiffening and intima-media thickness (IMT). Coronary flow reserve (CFR) measurement by transthoracic Doppler echocardiography (TTDE) reflects coronary microvascular and endothelial functions, as a cheaper and an easy screening test.
View Article and Find Full Text PDFBackground: The aim of our study was to evaluate the oxidant/antioxidant status of thyroid tissue in Graves' disease (GD) patients and to compare the results of GD thyroid tissue with plasma of patients and healthy controls.
Methods: We studied 25 consecutive patients with GD hyperthyroidism who underwent surgical treatment. The patients were divided into groups according to the duration of antithyroid drug treatment, the type of antithyroid drugs used, the presence of ophthalmopathy, and recurrence after a complete course of antithyroid drugs.
Article Synopsis
- The study focuses on improving successful parathyroid surgery through accurate preoperative tumor localization using ultrasound-guided fine needle aspiration (FNA) as a diagnostic tool for hyperparathyroidism patients.
- A total of 56 FNAs were performed on 27 patients, confirming parathyroid lesions with high mean parathyroid hormone (PTH) levels, demonstrating clear differentiation from thyroid aspirates.
- The findings show that US-guided FNA is a safe and effective method for confirming parathyroid lesions, achieving 100% sensitivity, thus enhancing patient selection for minimally invasive surgery.
Article Synopsis
- This study presents the first documented case of autoimmune thyroid encephalopathy resulting in multifocal motor status epilepticus in a 37-year-old woman.
- The patient exhibited severe symptoms, including intractable multifocal seizures and asymmetrical quadriparesis, with MRI revealing abnormal signals in the precentral cortices.
- After diagnosing autoimmune thyroiditis through thyroid examinations and function tests, the patient's seizures stopped following intravenous steroid treatment, suggesting the need for screening anti-thyroid antibodies in similar seizure cases.
Background: The widespread use of ultrasound, computerized tomography, and magnetic resonance imaging has led to an increase in the number of incidental adrenal masses identified. Asymptomatic incidentally discovered adrenal masses may indicate that subclinical Cushing syndrome (SCS) is not uncommon. We aimed to evaluate the cardiovascular risk of patients with SCS before and after surgery.
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- A 19-year-old female patient with a history of kidney stones and urinary tract infections was found to have low magnesium levels and high calcium levels, despite treatment with thiazide diuretics.
- Genetic testing revealed a specific mutation (G227R) in the CLDN16 gene, linked to her hypomagnesemia and hypercalciuria.
- This case highlights the hereditary nature of her condition, suggesting that even family members with a single copy of the mutation may be at risk for kidney stones.
A patient with an intrasellar germinoma leading to pituitary stalk thickening is reported. The patient, a 24-year old woman, presented with hyperprolactinemia, secondary hypothyroidism, and hypogonadotropic hypogonadism with no evidence of diabetes insipidus. Cerebrospinal fluid (CSF) examination revealed an increased number of lymphocytes and histiocytes.
View Article and Find Full Text PDFObjective: Although chronic physical illness may be associated coincidentally with an eating disorder, some clinicians may overlook the possibility that another medical illness may coexist and contribute concurrently to symptoms such as peculiar eating behaviors, restrictive eating, and/or vomiting accompanied by body dissatisfaction. We present a 31-year-old single woman initially diagnosed with an atypical eating disorder.
Method: After a gastroenterology consultation prompted by the atypical characteristics of her eating disturbance, the diagnosis of celiac disease was established.