Antimicrobial Activity of Ceragenins against Vancomycin-Susceptible and -Resistant spp.

Ceragenins (CSAs) are a new class of antimicrobial agents designed to mimic the activities of endogenous antimicrobial peptides. In this study, the antibacterial activities of various ceragenins (CSA-13, CSA-44, CSA-90, CSA-131, CSA-138, CSA-142, and CSA-192), linezolid, and daptomycin were assessed against 50 non-repeated spp. (17 of them vancomycin-resistant Enterococcus-VRE) isolated from various clinical specimens.

activities of antifungals alone and in combination with tigecycline against biofilms.

Background: may form biofilms, which are thought to underlie the most recalcitrant infections.

Methods: In this study, activities of antifungal agents alone and in combination with tigecycline against planktonic cells and mature and developing biofilms of isolates were evaluated.

Results: Amphotericin B and echinocandins were found to be the most effective agents against mature biofilms, whereas the least effective agent was fluconazole.