Constraints on Ultraheavy Dark Matter Properties from Dwarf Spheroidal Galaxies with LHAASO Observations.

In this Letter we try to search for signals generated by ultraheavy dark matter at the Large High Altitude Air Shower Observatory (LHAASO) data. We look for possible γ rays by dark matter annihilation or decay from 16 dwarf spheroidal galaxies in the field of view of the LHAASO. Dwarf spheroidal galaxies are among the most promising targets for indirect detection of dark matter that have low fluxes of astrophysical γ-ray background while having large amount of dark matter.

Measurements of All-Particle Energy Spectrum and Mean Logarithmic Mass of Cosmic Rays from 0.3 to 30 PeV with LHAASO-KM2A.

We present the measurements of all-particle energy spectrum and mean logarithmic mass of cosmic rays in the energy range of 0.3-30 PeV using data collected from LHAASO-KM2A between September 2021 and December 2022, which is based on a nearly composition-independent energy reconstruction method, achieving unprecedented accuracy. Our analysis reveals the position of the knee at 3.

Neutrino Signal from a Population of Seyfert Galaxies.

IceCube Collaboration has previously reported evidence for a neutrino signal from a Seyfert galaxy NGC 1068. This may suggest that all Seyfert galaxies emit neutrinos. To test this hypothesis, we identify the best candidate neutrino sources among nearby Seyfert galaxies, based on their hard x-ray properties.

Measurement of Ultra-High-Energy Diffuse Gamma-Ray Emission of the Galactic Plane from 10 TeV to 1 PeV with LHAASO-KM2A.

The diffuse Galactic γ-ray emission, mainly produced via interactions between cosmic rays and the interstellar medium and/or radiation field, is a very important probe of the distribution, propagation, and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of diffuse γ rays from the Galactic plane between 10 TeV and 1 PeV energies, with the square kilometer array of the Large High Altitude Air Shower Observatory (LHAASO). Diffuse emissions from the inner (15° View Article and Find Full Text PDF

A Review of the EUSO-Balloon Pathfinder for the JEM-EUSO Program.

is a pathfinder for , the mission concept of a spaceborne observatory which is designed to observe Ultra-High Energy Cosmic Ray (UHECR)-induced Extensive Air Showers (EAS) by detecting their UltraViolet (UV) light tracks "from above." On August 25, 2014, was launched from Timmins Stratospheric Balloon Base (Ontario, Canada) by the balloon division of the French Space Agency CNES. After reaching a floating altitude of 38 km, imaged the UV light in the wavelength range ∼290-500 nm for more than 5 hours using the key technologies of .

Supernova Origin of Cosmic Rays from a γ-Ray Signal in the Constellation III Region of the Large Magellanic Cloud.

Cosmic rays could be produced via shock acceleration powered by supernovae. The supernova hypothesis implies that each supernova injects, on average, some 10^{50}  erg in cosmic rays, while the shock acceleration model predicts a power law cosmic ray spectrum with the slope close to 2. Verification of these predictions requires measurement of the spectrum and power of cosmic ray injection from supernova population(s).

Signatures of a Two Million Year Old Supernova in the Spectra of Cosmic Ray Protons, Antiprotons, and Positrons.

The locally observed cosmic ray spectrum has several puzzling features, such as the excess of positrons and antiprotons above ~20  GeV and the discrepancy in the slopes of the spectra of cosmic ray protons and heavier nuclei in the TeV-PeV energy range. We show that these features are consistently explained by a nearby source which was active approximately two million years ago and has injected (2-3)×10^{50} erg in cosmic rays. The transient nature of the source and its overall energy budget point to the supernova origin of this local cosmic ray source.

Orthodontic elastic separator-induced periodontal abscess: a case report.

Aim. Orthodontic elastic bands were proposed as being the source of gingival abscesses that can rapidly lead to bone loss and teeth exfoliation. We report an adolescent, otherwise, healthy patient whose periodontal status was sound.

Low-energy break in the spectrum of Galactic cosmic rays.

Measurements of the low-energy spectrum of Galactic cosmic rays (GCRs) by detectors on or near Earth are affected by solar modulation. To overcome this difficulty, we consider nearby molecular clouds as GCR detectors outside the Solar System. Using γ-ray observations of the clouds by the Fermi telescope, we derive the spectrum of GCRs in the clouds from the observed γ-ray emission spectrum.

Universal properties of dark matter halos.

We discuss the universal relation between density and size of observed dark matter halos that was recently shown to hold on a wide range of scales, from dwarf galaxies to galaxy clusters. Predictions of cold dark matter (ΛCDM) N-body simulations are consistent with this relation. We demonstrate that this property of ΛCDM can be understood analytically in the secondary infall model.

Evidence for strong extragalactic magnetic fields from Fermi observations of TeV blazars.

Magnetic fields in galaxies are produced via the amplification of seed magnetic fields of unknown nature. The seed fields, which might exist in their initial form in the intergalactic medium, were never detected. We report a lower bound B > or = 3 x 10(-16) gauss on the strength of intergalactic magnetic fields, which stems from the nonobservation of GeV gamma-ray emission from electromagnetic cascade initiated by tera-electron volt gamma rays in intergalactic medium.

Limbal explants from cryopreserved cadaver human corneas. Immunofluorescence and light microscopy of epithelial cells growing in culture.

The aim of the present study was to determine whether human cadaver corneas, that were subject to cryopreservation, would be a source of migrating epithelial cells in vitro and what kind of morphological features these cells possess. Limbal explant culture was used for expanding the epithelial cells. Non-quantitative light microscopical examinations of the cultures within a period of 28 days were carried out.

Strategy for searching for a dark matter sterile neutrino.

We propose a strategy for how to look for dark matter particles possessing a radiative decay channel and derive constraints on their parameters from observations of x rays from our own Galaxy and its dwarf satellites. When applied to sterile neutrinos in the keV mass range this approach gives a significant improvement to restrictions on neutrino parameters compared with previous works.

Quantum cosmology of the brane universe.

We canonically quantize the dynamics of the brane universe embedded into the five-dimensional Schwarzschild-anti-de Sitter bulk space-time. We show that in the brane-world settings the formulation of the quantum cosmology, including the problem of initial conditions, is conceptually more simple than in the (3+1)-dimensional case. The Wheeler-DeWitt equation is a finite-difference equation.

Integrity of endothelium in cryopreserved human cornea.

The aim of the present study was to elaborate an optimal method for cryopreservation of human donor cornea for transplantation and to follow the morphological changes in the structure of the endothelial cell layer using scanning electron microscopy (SEM). Sixteen groups, with four donor cornea each, were cryopreserved at cooling rates of 1 degree C per min and 5 degree C per min. Four cryoprotectants (glycerol, dimethyl sulfoxide, 1,2-propanediol, polyethylene glycol-400) in two concentrations (5% and 10% v/v) were prepared on the bases of medium Optisol GS supplied with 20% v/v human serum albumin.

Large-scale extragalactic jets powered by very-high-energy gamma rays.

The radiative cooling of electrons responsible for the nonthermal synchrotron emission of large-scale jets of radiogalaxies and quasars requires quasicontinuous (in time and space) production of relativistic electrons throughout the jets over the scales exceeding 100 kpc. While in the standard paradigm of large-scale jets this implies in situ acceleration of electrons, we propose a different "nonacceleration" origin of these electrons, assuming that they are implemented all over the length of the jet through effective development of electromagnetic cascades initiated by extremely high-energy gamma rays injected into the jet from the central object.

[Tailed. New options in therapy of bronchial asthma].

Patients with mild and moderate bacterial bronchial asthma received tailed in a dose 8 mg/day for 15 days. Positive changes were registered in bronchial permeability, hemodynamics in the lesser circulation. Hydrocortisone and immune unbalance was corrected.

Interleukin production by human colostral cells after in vitro mitogen stimulation.

Human colostral cells were pulsed with PHA, Con A, or LPS and cultivated in serum-free medium. The culture supernatants were tested for IL-1 activity in C3H/HeJ thymocyte assay and for IL-2 activity on human lymphoblasts. The IL-1 activity was the highest at the 24th h of cultivation and IL-2 activity at the 48th h of cultivation.

Relationship between the effect of cyclophosphamide on adjuvant arthritis severity, skin allograft rejection and spleen cell cytotoxic activity in rats.

Cyclophosphamide, which has a poor immunosuppressive effect on adjuvant arthritis in rats, evokes an aggravating form of the disease when applied at a single low dose before rats' sensitization with complete Freund's adjuvant. However, cyclophosphamide administered by this method of treatment has no such enhancement effect on skin allograft rejection reaction; on the contrary, the rejection reaction was inhibited. Spleen cell cytotoxic activity against 51-Cr labelled chondrocytes significantly decreased in adjuvant arthritis, while in skin allograft rejection it increased during the latent period before the rejection reaction appeared.