Assessment of genotoxicity of silver nanoparticles on lymphocyte cells of albino rats using comet assay.

Silver nanoparticles, "AgNPs", represent a prominent nanoproduct, but most of the previous toxicity studies on its genotoxicity are still limited. The current study aimed to assess the genotoxicity of AgNPs on lymphocyte cells using comet assay and to study the recovery probability. It was conducted on 50 adult male albino rats divided into "Control group", 10 rats were injected intraperitoneal, "IP", with distilled water for 28 days, and "Test groups", 40 rats were injected "IP" with 13 ± 3 nm AgNPs for 28 days, subdivided into group I: 10 rats were injected with 2 mg/kg AgNPs, group Ia: 10 rats were injected with 2 mg/kg AgNPs and left for another 4 weeks without scarification, group II: 10 rats were injected with 4 mg/kg AgNPs, and group IIa: 10 rats were injected with 4 mg/kg and left for another 4 weeks without scarification.