Publications by authors named "Nermien M Sabry"
Corrigendum to "Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential Naprosyn® analogs as COX-1 and/or COX-2 inhibitors" [Bioorg. Chem. 76 (2018) 188-201].
Bioorg Chem
May 2022
Article Synopsis
- A series of novel 5-imino-4-thioxo-2-imidazolidinone derivatives were synthesized successfully using specific chemical reactions between N-arylcyanothioformamide and isocyanate derivatives, resulting in high yields and purity.
- These derivatives, when treated with an acidic medium, transformed into 4-thioxoimidazolidin-2,5-dione derivatives, with their structures identified through various spectroscopic techniques, confirming their successful synthesis.
- Notably, most of the synthesized compounds displayed significant anti-inflammatory activity, outperforming the reference drug celecoxib in inhibiting COX-1 and COX-2 enzymes, and their potential as anti-inflammatory agents was further analyzed through
Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn® analogs as COX-1 and/or COX-2 inhibitors.
Bioorg Chem
February 2018
Article Synopsis
- Inflammation is a vital process for survival but contributes significantly to health issues; recent research focuses on creating advanced anti-inflammatory drugs.
- Novel naproxen derivatives were synthesized, demonstrating strong anti-inflammatory effects and showing up to 100% oedema inhibition along with 92% enzyme inhibition.
- Some of these compounds were selected for anti-cancer screening, revealing promising growth inhibition rates against various cancer cell lines, thus highlighting their potential as non-steroidal anti-inflammatory and anti-cancer agents.
2-Amino-4-(4-chloro-phen-yl)-4H-chromeno[8,7-b]pyridine-3-carbonitrile.
Acta Crystallogr Sect E Struct Rep Online
April 2013
The asymmetric unit of the title compound, C19H12ClN3O, contains two mol-ecules with similar conformations. The 14 non-H atoms comprising the 4H-chromeno[8,7-b]pyridine residue are essentially coplanar (r.m.
View Article and Find Full Text PDFCondensation of 3-N,N-diethylaminophenol (1) with α-cyanocinnamonitriles (2a-c) and ethyl α-cyanocinnamates (2d-f) provided compounds 3a-f and 4a-c. 12H-Chromeno[2,3-d]pyrimidine derivatives 6, 11-13 and 16 were obtained by treatment of 4H-chromene compounds (3) with different electrophiles followed by nucleophilic reagents. Structures of these compounds were established on the basis of IR, UV, 1H NMR, 13C NMR and MS data.
View Article and Find Full Text PDFA series of diazipine, pyrimidine, fused triazolopyrimidine and imide derivatives were newly synthesized using 4-phenyl-but-3-en-2-one 1 as a starting material and compounds 2 and 9 are intermediates. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). All the compounds were interestingly less toxic than the reference drug.
View Article and Find Full Text PDFA series of heterocyclic derivatives was synthesized using (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester 1 as starting material. Treatment of 1 with 1 N NaOH or hydrazine hydrate afford the corresponding acid 2 and acid hydrazides 4 and 5, which were reacted with several reagents to produce some new peptido hetero-organic derivatives 6-12. The pharmacological screening showed that many of these newly synthesized compounds have good anti-inflammatory and analgesic activities comparable to diclofenac potassium and valdecoxib as reference drugs.
View Article and Find Full Text PDFTreatment of 3-cyanoacetyl indole 1 with the diazonium salts of 3-phenyl-5-aminopyrazole and 2-aminobenzimidazole afforded the corresponding hydrazones 4 and 5. 3-Cyanoacetyl indole reacted with phenylisothiocyanate to give the corresponding thioacetanilide derivative 7. Treatment of 7 with hydrazonoyl chlorides afforded the corresponding 1,3,4-thiadiazole derivatives 8a-f and 9.
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