Children with isolated growth hormone deficiency: Empty sella versus normal sella.

Background: Empty sella (ES) may be associated with variable clinical conditions ranging from the occasional discovery of a clinically asymptomatic pouch within the sella turcica to severe intracranial hypertension and rhinorrhea. The need for replacement hormone therapy in ES, as in other syndromes that may cause hypopituitarism, must be assessed for every single hormone, including growth hormone (GH).

Aim: To determine whether or not the presence of ES could allow some changes in the GH responses of the isolated growth hormone deficiency (GHD) patients.

Growth response of Egyptian children with idiopathic short stature during four years of growth hormone therapy.

Background: Multiple factors affect the growth response to recombinant human growth hormone (rhGH) in children with idiopathic short stature (ISS).

Aim: To evaluate the growth responses of children with ISS treated with rhGH, aiming to identify the predictors of growth response.

Materials And Methods: We studied 120 cases, 90 males (75%), with a mean age of 13.

Bone age is the best predictor of growth response to recombinant human growth hormone in Turner's syndrome.

Background And Objectives: Recombinant human growth hormone (rhGH) is approved for use in children with Turner's syndrome (TS) in most industrialized countries and is recommended in the recently issued guidelines. We determined the growth responses of girls who are treated with rhGH for TS, with an aim to identify the predictors of growth response.

Materials And Methods: Fifty-six prepubertal girls with TS, documented by peripheral blood karyotype, were enrolled.