Investigation of Vasculogenesis Inducing Biphasic Scaffolds for Bone Tissue Engineering.

Vascularization is the main obstacle for the bone tissue engineering strategies since the defect size is generally large. Incorporation of angiogenic factors is one of the strategies employed in order to accelerate vascularization and improve bone healing. In this study, a biphasic scaffold consisting of fibrous poly(lactide--glycolide) (PLGA) and poly(lactide--glycolide)--poly(ethylene glycol)--poly(lactide--glycolide) (PLGA-PEG-PLGA) hydrogel loaded with vascular endothelial growth factor-A (VEGF) inducer, GS4012, was constructed.

Fibrous bone tissue engineering scaffolds prepared by wet spinning of PLGA.

Having a self-healing capacity, bone is very well known to regenerate itself without leaving a scar. However, critical size defects due to trauma, tumor, disease, or infection involve bone graft surgeries in which complication rate is relatively at high levels. Bone tissue engineering appears as an alternative for grafting.