Prediction of Recurrence-Free and Overall Survival in Retroperitoneal Well-Differentiated and Dedifferentiated Liposarcoma After Surgery.

This study was aimed at creating an effective model for predicting the course of the disease in retroperitoneal well-differentiated (WDLPS) and dedifferentiated (DDLPS) liposarcomas after surgery. The study included 111 patients with WDLPS and 74 patients with DDLPS. We developed a methodology for stratification of patients into prognostic groups.

Retroperitoneal Liposarcoma: Rational Extent of Surgery Tailored to Grade of Malignancy.

This study was aimed at determining the indications for combined and organ-preserving operations. The study included 190 patients with retroperitoneal liposarcoma (RLPS). The influence of the following factors on the overall survival (OS) and recurrence-free survival (RFS) were studied: involvement of adjacent organs in the tumor, volume of surgical intervention.

TNM classification of malignant tumors: Eighth edition for retroperitoneal liposarcoma. Ways to improve.

Aim: This study was aimed at assessing the prognostic significance of the "TNM: Classification of Malignant Tumors" eighth edition (TNM8) in the most common retroperitoneal tumors - liposarcoma.

Methods: The study included 192 patients with retroperitoneal liposarcoma (RLPS). The distribution of patients by stages and survival in accordance with the TNM8 were studied.

[Active surgical approach for retroperitoneal liposarcoma].

Objective: To assess the influence of active surgical approach on the long-term postoperative outcomes in patients with retroperitoneal liposarcoma.

Material And Methods: A retrospective study included 190 patients with retroperitoneal liposarcoma. The effect of malignancy grade, adjuvant chemotherapy, number of separate tumor nodes in primary neoplasm and the first relapse, as well as the number of previous total resections on survival rate was analyzed.

[Gastrointestinal stromal duodenal tumors: diagnostic mistakes and modern approaches to treatment].

Gastrointestinal stromal duodenal tumors are rare diseases of small intestine. Duodenal GISTs may be giant; these neoplasms can also simulate malignancies of other organs. These features result diagnostic and treatment mistakes.

Surgical and combined treatment of patients with duodenal stromal tumors.

Objective: To evaluate the immediate and long-term results of surgical and combined treatment of patients with duodenal stromal tumors.

Material And Methods: There were 47 patients with duodenal stromal tumors for the period 2002-2019. All patients underwent treatment at the Blokhin National Cancer Research Center.

[Differentiated surgical approach for retroperitoneal non-organ liposarcoma].

Objective: To determine the indications for combined and organ-sparing surgery depending on malignancy grade of retroperitoneal liposarcoma.

Material And Methods: A retrospective study included 190 patients with retroperitoneal liposarcoma. Influence of malignancy grade, lesion of adjacent organs and resection/excision of adjacent organs on the overall and recurrence-free survival was studied.

[Retroperitoneal dedifferentiated liposarcomas: semi-quantitative assessment of the dedifferentiated component and prognosis].

Objective: To evaluate the impact of malignancy grade and the proportion of the dedifferentiated component (DC) in retroperitoneal dedifferentiated liposarcomas (DDLS) on the course and prognosis of the disease.

Material And Methods: The retrospective study enrolled 74 patients with primary retroperitoneal DDLS who underwent radical surgical treatment in the N.N.

Distal duodenectomy: a new option of surgical treatment for duodenal tumors.

Objective: To assess severity, safety and functional advisability of distal pancreatectomy using original surgical technique developed in the Blokhin National Medical Research Centre of Oncology.

Material And Methods: There were 10 patients with duodenal malignancies who have undergone distal pancreatectomy in the Blokhin National Medical Research Centre of Oncology for the period 2006-2018. Distal pancreatectomy for primary duodenal tumors was performed in 8 patients, 2 patients underwent surgery for external invasion of the duodenum.

[Spleen-preserving D2-lymphodissection in gastric cancer surgery].

Oncological advisability of spleen removal during surgical treatment of gastric cancer is arguable at present time. It is presented technique of spleen-preserving D2-lymphodissection used for gastric body and proximal part cancer which was applied in 155 patients. Control group included 197 patients who underwent gastrectomy with splenectomy.

[Combined operations by retroperitoneal liposarcomas].

Retrospective analysis of 228 patients with retroperitoneal liposarcoma, operated on in the Russian Oncology Center during 1971-2010, has been done. Of 223 performed operations, 124 were combined, i.e.

[Results of combined treatment of patients with metastatic gastric cancer. Case study].

We present the clinical observation of combined treatment of a patient with metastatic gastric cancer. The patient underwent combined chemotherapy for initially inoperable gastric cancer with metastases to the liver, paragastric lymph nodes, and peritoneal carcinomatosis with complete regression of distant metastases, which allowed radical surgery. The patient is currently under regular team observation without signs of disease.

[Clinico-morphological properties and surgical treatment results in retroperitoneal liposarcomas].

The separate clinico-morphological features of nonorganic retroperitoneal liposarcoma (NRL) and their prognostic value were studied in 200 patients. The type of primary NRL is histologically erentiated in 65.5%, myxoid in 16.

[Signet ring cancer of the stomach: clinico-morphological features, postsurgical results and prognosis].

Clinico-morphological features of signet ring cancer of the stomach were evaluated in 372 out of 2,308 gastric cancer patients undergoing gastroectomy or stomach resection. Signet ring tumor pathology occurs mostly in young females and younger patients generally. It features high incidence of early cancers, low frequency of metastatic spreading to lymph nodes (T1-T2), high frequency of immediate involvement of perigastric fatty tissues, peritoneum and ovaries and infrequent spreading to the liver.

[A theoretical model for assessing the relationship between "stage migration" and survival of gastric cancer patients after variable lymph node dissection].

Standard histological procedures identify metastatic gastric cancer in approximately 15% of cases of macroscopically unaltered lymph nodes. Such metastases evade detection after surgery due to inadequate lymph node dissection, thus increasing staging error. Consequently, about 15% of patients suffer from tumor which is actually more advanced than one diagnosed originally.

[Surgery for gastric carcinoma in patients with high risk of peritoneal metastases].

Survival in 242 cases of lymph dissection (D2) and 319 patients with (D1) operated on for gastric cancer was compared. D2 lymph dissection was not followed by higher survival rates in dealing with such gastric malignancies involving high risk of peritoneal metastases as signet ring cell, undifferentiated cell, diffuse-infiltrative, Borrmann type IV gastric cancer and complete involvement of the stomach. When D2 lymphoadenectomy was carried out for gastric adenocarcinoma, generally known to be rarely accompanied by peritoneal metastases, the end results were much better, even in cases of serosal invasion.

[Basic directions in studying cancer of the resected stomach].

The causes, incidence of, and the time of occurrence of cancer of the stomach resected for benign diseases are analyzed. The outcomes of 384 operations for recurrent gastric cancer, including 174 radical ones, are presented. The highest resectability was noted in late recurrence and following Bilroth-II gastrectomy with long-loop forward colonic anastomosis.

[Non-sporulating anaerobic bacteria and anastomosis failure in patients with gastric carcinoma].

Cases of anastomosis suture failure within the period from 1977 to 1987 and from 1988 to 1998 in 139 patients after various surgical operations for gastric carcinoma were analyzed. Infection in the cases of the anastomosis sUture failure at the early terms was mainly due to representatives of Enterobacteriaceae and at the later terms the failure was mainly due to non-sporulating anaerobes belonging to Bacteroidaceae. The data are indicative of the fact that the use of antimicrobials requires a differential approach.

[Molecular biological and clinical-morphological studies of gastric tumors associated with Epstein-Barr virus].

The paper presents the results of the studies of gastric cancer (GC) associated with Epstein-Barr virus (EBV) among the patients residing in 4 geographical regions. In situ hybridization (ISH) techniques revealed that 49(11.4%) of the 430 examinees were EBV positive (EBV+), the virus-specific marker mRNA-1 of EBV, EBER-1) was found to be present in 80-100) of tumor cells.

[Detection and characterization of gastric carcinoma associated with epstein-barr herpes virus].

The present investigation was carried out to estimate the incidence of Epstein-Barr virus (EBV)-associated cases among gastric carcinoma (GC) patients in Russia. Carcinoma specimens from 184 patients with GC treated at the Cancer Research Center were investigated by EBV encoded RNA-1 (EBER-1) in situ hybridization. Seventeen (9.

[Submerged esophago-intestinal anastomosis in surgical treatment of gastric cancer].

The short-term results of 1,605 gastrectomies performed for stomach cancer, using different types of esophagoenterostomy, are discussed. Anastomotic leakage is the main criterion for a choice of the most optimal procedure of forming an anastomosis. The contribution of the first and second rows of sutures to leakage is evaluated.

[Current principles of diagnosis and surgical treatment of non-organ retroperitoneal tumors].

The data on surgical treatment of 455 patients operated on for primary and recurrent non-organ retroperitoneal tumors (NRT) are discussed. 64.2% of tumors were resected; postoperative lethality was 8.

[Surgical treatment of adrenal gland tumors].

The data on surgical treatment of 146 patients with adrenal gland malignancies as well as literature on the problem are discussed.

[Possibilities of surgical treatment of gastric cancer recurrences depending on the type of previous resection].

The study deals with the end results of 375 surgeries performed for recurrent cancer of the stomach. Radical surgery was carried out in 168 cases (extirpation of the remaining part of stomach--140; repeated resection of stomach--12; extirpation of esophagoenterostomy--16). Stomach resection after Billroth-II with anterior long-loop colostomy created the best conditions for radical extirpation of the remaining stomach, while Billroth-I resection--the worst.