Hippo-YAP signaling activation and cross-talk with PI3K in oral cancer: A retrospective cohort study.

Objectives: This study aimed to investigate the clinical and prognostic relevance of the Hippo-YAP transactivators YAP1 and TAZ in oral squamous cell carcinoma, and their possible relationship with PI3K/mTOR pathway activation.

Materials And Methods: Immunohistochemical analysis of YAP1, TAZ, PIK3CA (p110α), p-AKT (Ser473), and p-S6 (Ser235) was performed in paraffin-embedded tissue specimens from 165 OSCC patients. Correlations between protein expression and clinical data were further assessed.

Risk factors associated with fixation-related complications in microsurgical free flap reconstruction of the mandible.

Background: Hardware complications (loosening of screws, infection, or exposure of the plate) in mandibular reconstruction with vascularized osseous free flaps impose significant morbidity, and frequently require revision surgery. Purpose of this study was to identify possible contributing factors for hardware complications.

Methods: This is a retrospective cohort study involving case series of patients who underwent microvascular mandible reconstructions between 2000 and 2020.