Publications by authors named "Nerea Castillo Flores"
Article Synopsis
- Some people are trying to figure out if waiting to cut the umbilical cord affects how much useful blood can be collected for banking.
- The study looked at data from hospitals in Spain where babies were born normally and compared how much blood was collected based on waiting 30 seconds, 60 seconds, or more than 120 seconds before clamping the cord.
- They found that while waiting longer means you get less blood overall, the important parts of the blood still remained good, so all the waiting times still work for storing the blood for later use.
Mesenchymal stromal cells in the treatment of pediatric hematopoietic cell transplantation-related complications (graft vs. host disease, hemorrhagic cystitis, graft failure and poor graft function): a single center experience.
Front Pediatr
May 2024
Objectives: To describe mesenchymal stromal cells (MSCs) in the treatment of hematopoietic stem cell transplantation (HSCT) complications and to assess its safety and efficacy.
Methods: Single-center retrospective study (2016-2023). Patients under 20 years who received MSCs for the treatment of HSCT-related complications were included.
Article Synopsis
- Individual comorbidities significantly influence nonrelapse mortality (NRM) rates in patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT), with key factors including pulmonary disease, hepatic issues, cardiac conditions, and renal dysfunction.
- A Simplified Comorbidity Index (SCI), which includes these comorbidities and age over 60, was created to categorize patients into five risk groups, showing NRM rates ranging from 11.4% to 49.9%.
- The SCI demonstrated strong predictive capability for NRM in both the development and external validation cohorts, outperforming the existing Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI).
Relapse after Allogeneic Stem Cell Transplantation of Acute Myelogenous Leukemia and Myelodysplastic Syndrome and the Importance of Second Cellular Therapy.
Transplant Cell Ther
September 2021
Patients with acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) generally have poor overall survival (OS). Interventions that result in improved OS after relapse are not well established. The efficacy of second cellular therapy and specific indications are matters of debate.
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- Older patients with advanced blood cancers are increasingly undergoing stem cell transplants, but their survival rates are still low.
- A study found that over half of the patients aged 50 and older had sarcopenia (muscle loss), which significantly affected their survival and recovery after the transplant.
- The findings suggest that tackling sarcopenia through targeted interventions could improve transplant outcomes for older patients, highlighting the need for further research.
The myriad of benefits of early palliative care (PC) integration in oncology are well established, and emerging evidence suggests that PC improves symptom burden, mood, and quality of life for hematopoietic cell transplant (HCT) recipients. Specific impact of PC consultation on outcomes of older allogeneic HCT (allo-HCT) recipients, a historically high-risk population vulnerable to transplant-related complications and mortality, has not been explored. In this single institution, retrospective analysis of 527 first allo-HCT recipients aged ≥60 years, we characterized 75 patients who had received post-HCT PC consultation and its association with geriatric vulnerabilities identified by pre-HCT geriatric assessment.
View Article and Find Full Text PDFBackground: Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations in the composition of human microbial communities and differences in clinical practices across institutions raise the question of whether these associations are generalizable.
Methods: The microbiota composition of fecal samples obtained from patients who were undergoing allogeneic hematopoietic-cell transplantation at four centers was profiled by means of 16S ribosomal RNA gene sequencing.