Parameters of TNF receptor co-expression in allergic and autoimmune processes: Differences and diagnostic significance.

The authors used a method quantitative estimation density of TNFR1/TNFR2 on cells by flow cytometry with calibration particles, which allowed them to estimate the absolute number of receptors on cells regardless of the type of flow cytometer. The TNF receptor expression parameters were used to determine their association with the fact of disease and to build diagnostic models. The proposed methodological approach using a combination of flow cytometry and mathematical modeling techniques represents a promising direction for testing the diagnostic and prognostic significance of the studied biomarkers.

Intravenous amino acid therapy for kidney protection in cardiac surgery a protocol for a multi-centre randomized blinded placebo controlled clinical trial. The PROTECTION trial.

Background: Postoperative acute kidney injury (AKI) is frequent in cardiac surgery patients. Its pathophysiology is complex and involves decreased renal perfusion. Preliminary clinical evidence in critically ill patients shows that amino acids infusion increases renal blood flow and may decrease the incidence and severity of AKI.

Phosphocreatine in Cardiac Surgery Patients: A Meta-Analysis of Randomized Controlled Trials.

Objective: There is experimental evidence that phosphocreatine (PCr) can decrease ischemia/reperfusion injury of the heart. The authors investigated if PCr would improve heart performance as compared with standard treatment in cardiac surgery.

Design: Meta-analysis of randomized controlled trials.

Efficacy and Safety of Fibrinogen Concentrate in Surgical Patients: A Meta-Analysis of Randomized Controlled Trials.

Objectives: To investigate the efficacy and safety of fibrinogen concentrate (FC) in surgical patients.

Design: Meta-analysis of randomized controlled studies (RCTs).

Setting: Perioperative.

[The behavior of male Danio rerio after exposure of fish embryos to a simulated geomagnetic storm].

Embryos of the zebrafish, Danio rerio, were exposed to a simulated geomagnetic storm during 24 hours. Fish, developed from these embryos, left a start chamber to an aquarium more readily in comparison to those reared in a normal geomagnetic field. On the other hand, general locomotor activity in fish was not essentially different between the two groups.

Infusion of 7.2% NaCl/6% hydroxyethyl starch 200/0.5 in on-pump coronary artery bypass surgery patients: a randomized, single-blind pilot study.

Background: NaCl 7.2%/6% hydroxyethyl starch (HES) 200/0.5 (HSH) has shown its beneficial effects in cardiac surgery and immunomodulatory values in experiment and human studies.

[Magnetic fields and fish behavior].

In the review, contemporary data on the influence of natural and artificial magnetic fields on fish behavior are considered. In this regard, elasmobranchs and teleosts appear to be studied most exhaustively. Elasmobranchs and some teleosts are able to perceive magnetic fields via electroreceptors.

[Variability in invertebrate behavior and the problem of free will].

Behavior in animals, including invertebrates, varies spontaneously. The spontaneous variability results from nonlinear stochastic processes in nervous system. Some researchers believe this stochastic variability to be a basis for free will.

Oxidative stress and liver monooxygenase function after heart valve surgery.

Background And Objectives: this prospective study was carried out to evaluate oxidative stress and liver monooxygenase function after cardiac surgery in patients with acquired valvular heart disease.

Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled trienes, hepatocuprein, and catalase activity.

[The increase of variability in animal behavior due to autocorrelations].

We consider a simple kind of variability in animal instinctive behavior. It is comprised of switching between alternative actions. It consists also of variations in intensity of consecutive actions.

Hypertonic solution decreases extravascular lung water in cardiac patients undergoing cardiopulmonary bypass surgery.

Objective: To test the hypothesis that the infusion of hypertonic solution would decrease extravascular lung water postoperatively and thus improve pulmonary function.

Design: Prospective, randomized, blinded trial.

Setting: Tertiary cardiothoracic referral center.

[Comparison of two kinds of functional asymmetry in the roach Rutilus rutilus (teleostei: cyprinidae)].

In the higher vertebrates, asymmetries of different functions of individual are poorly connected with each other. At present it is unknown whether this poor link is a secondary phenomenon or it is characteristic of different kinds of functional asymmetry already at early stages of vertebrate evolution. In connection with this problem, in the roach Rutilus rutilus we studied asymmetry of two behavioral reactions--movements in an annular corridor and of the C-shaped body bending at a sudden action of electrical stimulus.

[Lipid peroxidation and cytochrome P-450-dependent metabolism of xenobiotics in patients with coronary heart disease and multiple organ failure].

The aim of the investigation was to study oxidative stress and hepatic monooxygenase function (HMF) in coronary heart disease (CHD) patients with multiple organ dysfunction (MOD) after myocardial revascularization. Twenty-seven CHD patients with signs of MOD and 38 patients with an uncomplicated postoperative period were examined. The intensity of MOD was rated by the SOFA scale; oxidative stress was estimated from the values of malondialdehyde, conjugate trienes, ceruplasmin, and catalase, and HMF was evaluated from antipyrine pharmacokinetic data.

Oxidative stress and monooxygenase liver function in patients with coronary heart disease and multiple organ dysfunction syndrome.

Background And Objective: The purpose of the study was to evaluate oxidative stress and liver monooxygenase function in patients with coronary heart disease and multiple organ dysfunction syndrome.

Methods: Twenty-seven patients with multiple organ dysfunction and 38 patients with an uneventful postoperative period were studied. Oxidative stress was quantified with malon dialdehyde, coupled trienes, hepatocuprein and catalase activity.

[Habituation of caddies Chaetopteryx villosa larvae to vibrational stimulus and effect of piracetam on it].

Habituation to a vibrational stimulus was studied in intact caddies Chaetopteryx villosa Fabr. of the last age before pupation and of the larvae placed for 72 h into pyracetam solution (100 mg/l). The vibrational stimulus was shown to produce a passive-defensive reaction: the caddies were pulled into the house and stood still.

[Laterality of the initial stage of escape response in roach (Rutilus rutilus) upon impact of alternating electric current].

The initial stage of the escape response (C-bend of the body) upon sudden impact of electric current on free-swimming fish was studied in young roach (Rutilus rutilus). More than half of the fish showed distinct behavioral laterality. i.

[Oxidative stress and hepatic monooxygenase function in patients with coronary heart disease before and after cardiac surgery].

The parameters of lipid peroxidation (LPO) and hepatic monooxygenase function (HMF) were studied in 92 patients with coronary heart disease (CHD). After termination of and within the first 24 hours after myocardial revascularization, the levels of malonic dialdehyde and conjugate trienes were found to show 45.6 and 62.

[The conflict between optimisation and orderliness in building behaviour of the caddis fly, Chaetopteryx villosa Fabr.(Limnephilidae: Trichoptera), larvae].

The Optimal Foraging Theory predict that an animal should restrict its searching activity to those patches of environment, where the ratio of gain to time and energy spent is maximal. Experimenters usually verify the prediction against the null hypothesis of random activity distribution between patches. As animals always prefer profitable patches to some degree, experimental results can always be interpreted as confirmation of the theory.

[Normobaric hypoxy-therapy of patients with bronchial asthma].

Conventional drug therapy for moderate atopic or mixed bronchial asthma was combined with normobaric hypoxytherapy (NBHT) in 32 patients (a course of 10 sessions) and was not combined in 20 control patients. Clinical results show that NBHT enhances response to conventional therapy of moderate bronchial asthma as confirmed by a significant relief of the clinical symptoms, by a significant rise of volumic and flow parameters of external respiration function, a fall in the number of CD 20+ B cells, low level of serum IgE, increased number of phagocyting neutrophils and cells carrying erythroblast antigen in peripheral blood.

[The variability of the reaction to a visual stimulus in goldfish, Carassius auratus L. (Cyprinidae: Pisces)].

Animal's responses to repeated identical stimulation are notoriously variable. The variability is not always resulted from differences between individuals, stimulus action, or habituation. Goldfish's responses to a visual stimulus were studied in order to reveal the nature of variability.

[Cerebral, central and intracardiac hemodynamics in patients with progressive arterial hypertension following the surgical suppression of adrenal hyperfunction].

Forty-eight patients with progressive (malignant) arterial hypertension resistant to conservative therapy were subjected to surgical portalization of the adrenal blood stream in order to metabolize excessively produced aldosterone in the liver of the patients. Cerebral hemodynamics was studied before by tetra- and bipolar rheoencephalography, central hemodynamics was studied by tetrapolar transthoracic rheography, and intracardiac hemodynamics by echocardiography before and after surgery; blood plasma aldosterone and hydrocortisone concentrations and plasma renin activity were measured. A significant reduction of arterial pressure, elimination or alleviation of subjective and objective manifestations of chronic hypertensive encephalopathy were seen in the majority of patients after surgery.

[The indications for the suppression of adrenal hyperfunction in a progressive course of hypertension].

The authors analyze the results of the surgical treatment of patients with progressive essential hypertension (PEN). The treatment involved cryodestruction (adrenalectomy) of the right adrenal and autotransplantation of the left adrenal on the vascular peduncle into the transverse mesentery. Before the operation the data on water-salt homeostasis, central and cerebral hemodynamics and on the renin-angiotensin-aldosterone system attested to PEH.