[Morphofunctional changes in gastrointestinal tract in patients with psoriasis accompanied by chronic opisthorchosis].

The paper covers clinical, morphological and functional aspects of gastrointestinal tract condition in patients with psoriasis accompanied by chronic opisthorchosis (CO). The authors examined 150 patients with psoriasis accompanied by CO, 100 patients having psoriasis without helminthiasis, 100 patients with CO and 30 healthy people. The gastric secretion was evaluated by means of the fractional test (both phases) with histamine stimulation; other diagnostic procedures included carbohydrate absorption evaluation (5-gram D-Xylose absorption test) and Kamer test of fat absorption.

[Clinical endoscopic and pathomorphologic study of the stomach in vibration disease].

The authors present results of manifold evaluation of stomach in 109 patients with vibration disease caused by various vibration characteristics. The evaluation covered clinical signs, laboratory studies, endoscopic and pathomorphologic methods with light and electronic microscopy, in vitro radioautography and morphostereologic analysis. Features of gastric disease in vibration disease are asymptomatic course, depressed gastric secretion, prevalent atrophic changes of mucosa on endoscopy.

[The clinical and structural-metabolic characteristics of atrophic forms of chronic bronchitis].

A clinical-morphological study of bronchobiopsies from 78 patients with endoscopic picture of atrophic endobronchitis was carried out. Two forms of morphogenesis of chronic atrophic process in the bronchial mucosa are distinguished: primary dystrophic and primary inflammatory. Primary dystrophic bronchopathy is a clinical manifestations of the first form which presents structurally and functionally as primary dystrophy and atrophy of the bronchial mucosa in combination with sclerosis of the lamina propria in a sharp decrease of synthetic processes in bronchial epitheliocytes as indicated by the data of autoradiography.

[A stereological analysis of the myocardium in rats adapting to the conditions at high latitudes].

Qualitative and quantitative morphologic analysis of myocardium of Wistar rats were carried out when they have been transferred to high latitudes (being in latitude 69 degrees north during 37 days). It was shown, that already in a day after transferring to high latitudes pronounced disorders of lymph and blood circulations developed and heterogeneity of cardiomyocyte lesions was noted. By the end of the experiment atrophic and necrobiotic cardiomyocytes resorbed by macrophages were registered.

[The intravital pathologicoanatomical diagnosis and prognosis of chronic inflammatory processes in the lungs].

Bronchial biopsies and bronchoalveolar lavage (BAL) in 226 patients with chronic inflammatory pulmonary diseases of different genesis were studied using light and electron microscopies and radioautography. 76 patients were treated with endobronchial laser therapy. Two types of structural-functional reorganization of epithelium in large bronchi were established: atrophy and squamous metaplasia both accompanied by the decrease of metabolic activity of epitheliocytes, but differing in DNA synthesis level.

[Chronic inflammatory processes in the lungs: their intravital pathologicoanatomic diagnosis and prognosis].

Combined morphological study of 714 bronchial biopsies and 363 samples of bronchoalveolar lavage (BAL) from 560 patients with chronic inflammatory diseases of nonspecific and tuberculous etiology was carried out. By light microscopic, electron microscopic and radioautographic investigation it was shown, that more important criteria of the dynamics of pathologic process, the stages of compensatory-adaptive reorganization of the lungs and the prognosis of disease were the structural-metabolic transformation of surface epithelium (metaplasia to stratified squamous epithelium or its atrophy) and the quantitative-qualitative characteristics of alveolar macrophages. A correlation was revealed between metabolic activity of BAL cells and those of bronchial epithelial cells, which determined the structural-functional interaction between the airways and respiratory part of the lungs under chronic inflammatory processes and promoted the right interpretation of clinical and morphological data.

[Immunohistochemical characteristics of chronic erosion of the gastric mucosa].

By methods of immunohistochemistry, light and electron microscopies gastrobiopsies from regions of acute and chronic erosions and border zones of gastric mucosa were studied in 36 patients with erosive gastritis. There was determined the decrease of amount of IgA-producing cells against a background of the increase of IgG-producing plasmocytes in the zone of mucosal defect. IgG-precipitations and fixation of heterogeneous complement in fibrinoid necrosis of erosive defect were revealed.

[An electron microscopic and radioautographic study of bronchoalveolar lavage in chronic inflammation of the lungs under the effects of helium-neon laser].

136 samples of bronchoalveolar lavage (BAL) from 45 men-patients with chronic inflammatory processes of lung were studied in course of endobronchial laser influence. It was shown, that considerable quantitative and qualitative changes in cell composition of BAL-fluid were resulted from helium-neon laser influence, these are the percentage increase of macrophage amount and the decrease of neutrophil numbers. By use of radioautographic analysis the stimulation of metabolic and proliferative reactions (on the level of RNA and DNA syntheses) of alveolar macrophages under laser influence was found.

[True pemphigus: electron microscopic and radioautographic research on the skin].

Skin biopsy specimens of 19 patients with pemphigus vulgaris have been examined by electron microscopy and radioautography. Ultrastructural changes in the epidermocytes (impaired nucleolar system, lysis of the cytoplasmic organelles, disappearance of desmosomes) reflect impaired protein biosynthesis. In vitro radioautography with 3H uridine and 3H thymidine has shown inadequate RNA and DNA synthesis in the epidermal cells.

[Ultrastructural and radioautographic research on the skin in acantholysis bullosa].

By means of light microscopy 145 biopsies of skin in acantholytic pemphigus were studied. Electron microscopic and radioautographic study was carried out in 19 cases. It was determined that the whole complex of ultrastructural changes in epidermocytes (impairment of nucleolar apparatus, lysis of cytoplasmic organelles, disappearance of desmosomes) reflects the disturbance of protein synthesis.

[Electron microscopic and radioautographic study of the bronchi in chronic inflammation as affected by helium-neon laser treatment].

Structural-metabolic changes were studied in 98 biopsies of large bronchial mucosa from 39 male patients with chronic suppurative lung diseases. It was shown (by the level of DNA and RNA synthesis) that the proliferative and metabolic processes were induced by endobronchial treatment of the damaged epithelium with helium-neon laser which passing through a number of transitional stage recovers its structure and differentiation to ciliary and goblet cells with normal ultrastructure. In lamina propria hyperemia, intensive leukodiapedesis, leukocyte infiltrates and granulations develop and proliferative and metabolic activity of endotheliocytes and interstitial cells increases, which results in the formation of delicate fibrous connective tissue.

[Histostereologic analysis of the myocardium of homoiothermic animals during cooling].

A stereologic study of the myocardium exposure to cold for 4 hours, 8 and 16 days was carried out on Wistar rats. It has been shown that during the first 8 days acute hemodynamic disorders and cardiomyocyte contractures developed. These changes were followed by a decrease in the volume and surface capillary density resulting in the impairment of transcapillary exchange and reduction of the intracellular regeneration processes in cardiomyocytes.