[The usefulness of neo- and adjuvant therapy in the treatment of cutaneous melanoma].

One hundred-thirty seven patients with recurrences and metastases of skin melanoma (stage II-III) were divided into four groups in a retrospective study. In group I, there was no adjuvant therapy (47); it was given for 35 +/- 5 days after surgery in group II (31); for 1-2 days after surgery in group III (31). In group IV, neoadjuvant therapy (NAT) was administered by way of preparing for surgery and adjuvant therapy (41).

[Sweat gland polyneoplasia with extensive metastases].

The paper describes a case of sweat gland polyneoplasia with extensive metastases in a 47-year-old woman, which is indicative of extreme malignancy of this tumor.

[Prognostic significance of some markers in cutaneous melanoma treated with different therapeutic modalities].

The paper discusses the prognostic significance of Ki-67, bcl-2 and HMB-45 markers in skin melanoma in the course of different modalities of chemotherapy involving autoblood. Recurrence-free and 3-year survival among patients receiving autoblood preparations was significantly higher than in controls (p < or = 0.05).

[Clinico-morpho-sonographic parallels in skin melanoma].

Data on sonographic features of different variants of skin melanoma are presented. Relationship between skin to tumor thickness ratio and invasion depth (Clark) or tumor thickness (Breslow) were found. Tumor extent was effectively identified by ultrasound tomography of primary focus preoperatively.

[A comparative study of free radical-assisted processes and antioxidant protection of certain areas of liver involvement].

Light sum of chemiluminescence, concentrations of malonic dialdehyde, superoxidismutase and catalase were studied in intact liver tissue. The rate of free radical processes and super-oxidismutase level in liver metastases were lower than in intact tissue. Free radical concentration in the perifocal zone of liver metastases was lower too, which might have stimulated proliferation in metastatic foci.

[Pathologoanatomic characteristic of primary and metastatic liver carcinoma].

Results of the analysis of primary and metastatic liver carcinoma, by using autopsied specimens in Rostov-on Don over 20 years are presented. The frequency of hepatocellular carcinoma was 0.4% among the deceased and 3.

[Generalized Kaposi's sarcoma after allogenic transplantation of cadaver kidney].

A case report of generalized Kaposi's sarcoma in a 41 year old patient, which developed 3.5 years after allogenic cadaver kidney transplantation with terminal chronic kidney insufficiency caused by chronic intracapillary glomerulonephritis. The peculiar feature was a visceral form of the disease with affection of the stomach, intestinal mesentery and cerebral dura mater without skin manifestations.

[Tropical malaria with a fatal outcome in the Rostov region].

Epidemiological data on malaria in the Rostov region are presented. An autopsy case of tropical malaria in a 63-year-old man infected in Uganda is described. Treatment was ineffective.

[Importance of urgent histological investigation in surgical treatment of biliopancreatoduodenal zone carcinoma].

Urgent intraoperative investigation allows a surgeon, depending on the morphological conclusion, to conduct individual surgical intervention in the form of anastomosis with penetration into the tissue of the pancreas. The method decreases the rate of surgical complications, improves immediate results of patient treatment and reduces postoperative lethality. This proves the importance of morphology in the surgical treatment of tumours in the zone concerned.

[Pathologic morphology of cervical carcinoma with endolymphatic infusion of immuno-modulating drugs].

Prior to standard therapy, an immunomodulator was administered by endolymphic infusion to 85 patients with cervical carcinoma (T3NxMo), with a view to reinforce treatment. The drug was fed to lymph collectors which were regional and aregional with respect to tumor. Also, the treatment was supplemented with regional infusion of considerable doses of cytostatic mixes.

[Histologic tissue processing in an automated microwave histoprocessor].

A new vacuum histoprocessor has been tested as well as new more effective protocols to work with this processor. The device allows histoprocessing of 50 samples simultaneously of surgery, biopsy or autopsy material during 1-1.5 h.

[Superoxide-neutralizing activity of blood serum in cases of primary multiple malignant tumors].

An earlier investigation of the superoxide-neutralizing activity of blood serum sampled from patients with primary multiple malignancies detected for the first time RF-proteins as well as their tropism to the target organ from which tumor was removed 2-30 years before. A possible explanation may be that a general reaction of the body presented itself. The present study has led to a conclusion that, in cases of polyneoplasia, successful complex treatment of primary malignancy, carried out however for back, might be masked by RF-protein function: the latter "indicates" the presence of foci of malignancy which are not there any longer.

[Melanoma of the mucosa of the mouth and upper respiratory tract].

3 cases of extracutaneous melanoma are described: those of the alveolar process of maxilla, nose septum and ethmoidal cavity. Clinical symptoms were nose haemorrhages, difficulties of the nose respiration, pains in the month. Histologically melanomas were of a typical structure being formed of the epithelioid and naevus-like cells with high content of melanine with an extra- and intracellular location.

[Pulmonary berylliosis].

A case of a chronic lung berylliosis in a 20-year-old woman with a 20-weeks pregnancy is described. The diagnosis is established on the basis of morphological features: fibrosing alveolitis with numerous lympho-histiocytic granulomas containing conchoidal bodies and the lung tissue chemical analysis showing the presence of beryllium (2.71 X 10(-6) g/organ).

[Intralobar sequestration of the lungs].

The paper deals with 6 cases of intralobar pulmonary sequestration that is a rare developmental defect accompanied by other anomalies and tumors. In 4 cases, the diagnosis was made on the basis of X-ray and bronchologic examinations before surgery, in 2 cases, during the surgery. The morphologic features were found to be cystic formations accompanied by chronic inflammation in the lung tissue, cylindrical brochiectasis along with celomic cyst of the pericardium and microcarcinoid in the cyst wall.