Publications by authors named "Neos Tang"
Human infections with highly pathogenic avian influenza H5N1 viruses persist as a major global health concern. Vaccination remains the primary protective strategy against H5N1 and other novel avian influenza virus infections. We investigated the use of type IIb heat labile enterotoxin B subunit (LTIIb-B5) as a mucosal adjuvant for intranasal immunizations with recombinant HA proteins against H5N1 avian influenza viruses.
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- Highly pathogenic avian influenza viruses are serious threats to bird health, and this study explores new ways to create effective mucosal vaccines against them.
- Researchers developed a fusion protein of the H5 influenza virus and a heat-labile enterotoxin (LTIIb) to improve immune responses in both mice and chickens through intranasal immunizations.
- Results showed that this new approach significantly increased antibody production and protective responses against the H5N1 virus, suggesting it could lead to better vaccines for avian influenza.
Researchers are currently involved in a strong effort to find a safe and effective vaccine against highly pathogenic avian influenza H5N1 viruses. Toward that goal, we obtained soluble recombinant flagellin (FliC) of Salmonella typhimurium to be used as a mucosal adjuvant for H5HA subunit vaccine development. Intranasal immunization of H5HA antigen with recombinant FliC protein in an oil-in-water emulsion increased H5HA-specific IgG and IgA titers in sera, bronchoalveolar lavage fluids (BALFs), and nasal washes.
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