Publications by authors named "Neona Lowe"

Extracellular vesicles (EVs) are diverse nanoparticles with large heterogeneity in size and molecular composition. Although this heterogeneity provides high diagnostic value for liquid biopsy and confers many exploitable functions for therapeutic applications in cancer detection, wound healing and neurodegenerative and cardiovascular diseases, it has also impeded their clinical translation-hence heterogeneity acts as a double-edged sword. Here we review the impact of subpopulation heterogeneity on EV function and identify key cornerstones for addressing heterogeneity in the context of modern analytical platforms with single-particle resolution.

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Article Synopsis
  • This review looks at clinical trials involving extracellular vesicles (EVs), which are tiny particles that can help with diagnosing and treating diseases.
  • The study found 471 EV-related trials, mostly focusing on cancer and respiratory illnesses, using certain methods like ultracentrifugation to study EVs.
  • The authors believe that paying more attention to different types of EVs could lead to better treatments in the future, pushing for improved methods and reporting in research.
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Article Synopsis
  • * Circulating extracellular vesicles (EVs) from patients are promising as sepsis biomarkers, as they are linked to bacterial activity and immune response.
  • * This study uses Raman spectroscopy on EVs from patient plasma, achieving high sensitivity (97.5%) and specificity (90.0%) in detecting sepsis, indicating their potential as effective diagnostic tools in burn care.
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Since extracellular vesicles (EVs) have emerged as a promising drug delivery system, diverse methods have been used to load them with active pharmaceutical ingredients (API) in preclinical and clinical studies. However, there is yet to be an engineered EV formulation approved for human use, a barrier driven in part by the intrinsic heterogeneity of EVs. API loading is rarely assessed in the context of single vesicle measurements of physicochemical properties but is likely administered in a heterogeneous fashion to the detriment of a consistent product.

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Sepsis following burn trauma is a global complication with high mortality, with ~60% of burn patient deaths resulting from infectious complications. Sepsis diagnosis is complicated by confounding clinical manifestations of the burn injury, and current biomarkers markers lack the sensitivity and specificity required for prompt treatment. Circulating extracellular vesicles (EVs) from patient liquid biopsy as biomarkers of sepsis due to their release by pathogens from bacterial biofilms and roles in subsequent immune response.

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HIV and hepatitis B are two of the most prevalent viruses globally, and despite readily available preventive treatments unforgiving treatment regimens still exist, such as daily doses of medicine that are challenging to maintain especially in poorer countries. More advanced and longer-lasting delivery vehicles can potentially overcome this problem by reducing maintenance requirements and significantly increase access to medicine. Here, we designed a technology to control the delivery of an antiviral drug over a long timeframe via a nanofiber based delivery scaffold that is both easy to produce and use.

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