Synthesis, characterization, interactions with 9-MeG and cytotoxic activity of heterobimetallic Ru-Pt complexes bridged with 2, 2'-bipyrimidine.

The complexes [(η-bz)Ru(bpm)Cl]PF, (1)PF, [(η-bz)ClRu(μ-bpm)PtCl]PF, (2)PF, [(η-cym)ClRu(μ-bpm)PtCl]PF, (3)PF, [(η-cym)ClRu(μ-bpm)PdCl]PF, (4)PF, [Pt(bpm)(cbdca)], (5) and [(η-cym)ClRu(μ-bpm)Pt(cbdca)]PF, (6)PF, (bz = benzene, bpm = 2,2'-bipyrimidine, cym = p-cymene, cbdcaH = 1,1-cyclobutanedicarboxylic acid),were synthesized and characterized by means of H NMR and high-resolution ESI mass spectrometry. The complexes were transformed to the corresponding chloride salts to become soluble in aqueous media, and to be studied regarding their biological properties. However, while the heterobimetallic complexes (3)Cl and (6)Cl were almost stable, (2)Cl and (4)Cl were decomposed.