Novel hybrids of podophyllotoxin and formononetin inhibit the growth, migration and invasion of lung cancer cells.

In this study, three hybrids of podophyllotoxin and formononetin were synthesized and evaluated for anticancer efficacy. Some of the derivatives exhibited potent cytotoxicity against a panel of human and mouse cancer cell lines, with IC values in the low micromolar to submicromolar range. Evaluation against A549 lung tumor cell line identified that the IC value of compound 10a was 0.