Publications by authors named "Nengshu He"
Purpose: To evaluate the effects of short-term intra-arterial delivery of paclitaxel on neointimal hyperplasia and the local thrombotic environment after angioplasty.
Methods: An experimental common carotid artery injury model was established in 60 rats, which were divided into experimental groups (40 rats) and controls (20 rats). Local intra-arterial administration of paclitaxel was applied at 2 doses (90 and 180 μg/30 μl), and the effects of short-term delivery of paclitaxel on neointimal hyperplasia and the expression of tissue factor (TF), plasminogen activator inhibitor-1 (PAI-1) and tissue-type plasminogen activator (t-PA) were evaluated at days 15 and 30 by hematoxylin and eosin staining and immunohistochemistry.
Objective: To lessen the occurrence of contrast-induced nephropathy (CIN), the preventive measures of CIN were reviewed.
Data Sources: The data used in this review were from PubMed with relevant English articles and from Chinese Knowledge Information (CNKI) published from 1989 to 2009. The search terms were "contrast medium", "contrast-induced nephropathy" and "prevention".
Purpose: Massive pulmonary embolism (PE) causes hemodynamic compromise and is associated with a high rate of mortality. We sought to create a model of massive PE and to determine whether occlusion of the right main bronchus could mitigate the physiological effects of massive PE in this model.
Materials And Methods: We used 27 female sheep to generate a model of massive PE by either autologous blood clot injection (n=18) or detachable balloon release (n=9) into the right main pulmonary artery.
[Comparison of the massive pulmonary embolism of the animal model stabled by different methods].
Zhonghua Jie He He Hu Xi Za Zhi
May 2010
Objective: To contrast the massive pulmonary embolism of the animal model had been stabled by inserting the animal's own blood clots or through use of detachable latex balloons.
Methods: Eighteen healthy sheep were separated as three groups with random. We established the animal lung, PE model by inserting the animal's own blood clots at right lung artery in 6 sheep, and 6 sheep were through used of detachable latex balloons to substitute the blood clots.
Endovascular stenting in isolated dissection of superior mesenteric artery.
Chin Med J (Engl)
December 2009
Purpose: To evaluate and compare the results of percutaneous transluminal angioplasty (PTA) and stent placement to treat femoropopliteal artery occlusive disease.
Materials And Methods: Published data of randomized clinical trials comparing the results of PTA and stent placement for femoropopliteal artery occlusive disease were analyzed. Proportions were combined, and the odds ratio (OR) with its 95% CI was used as the effect size estimate.
Objective: To observe the developing changes of adventitia in restenosis after precutaneous transluminal angioplasty(PTA), and investigate the effect of androgen on restenosis through contrasting the castrated male rat models and its mechanism.
Methods: Models were constructed of castrated male rats and restenosis of the common carotid artery, and specimens were collected at the 3rd, 7th, 14th and 28th day respectively after modeling. Hematoxylin and eosin staining, immunohistochemical staining, and electronic microscopy were performed to observe the condition of restenosis.
Interventional and synthetic therapy of advanced hepatocellular carcinoma.
Chin Med J (Engl)
December 2002
Objective: To evaluate the clinical efficacy of interventional therapy in the treatment of hepatocellular carcinoma (HCC).
Methods: Thirty-three patients with HCC were synthetically treated by systematic measures. Among them, percutaneous port-catheter system (PCS) implantation via the femoral artery was performed in 21 cases.