Publications by authors named "Neng-Neng Cheng"

Glutamate is the major excitatory neurotransmitter in the brain and plays an essential role in regulating wakefulness. Histaminergic neurons, which are exclusively localized in the tuberomammillary nucleus (TMN) of the hypothalamus, have a pivotal role in the regulation of sleep-wake patterns by sending widespread projections into many brain areas implicated in sleep-wake control. The role of glutamate in histaminergic neurons within the TMN and the resulting sleep-wake profile remains unknown.

View Article and Find Full Text PDF

Rational: Neuropathic pain is frequently comorbid with sleep disturbances. Paeoniflorin, a main active compound of total glucosides of paeony, has been well documented to exhibit neuroprotective bioactivity.

Objective: The present study evaluated effects of paeoniflorin on neuropathic pain and associated insomnia and the mechanisms involved.

View Article and Find Full Text PDF

Xiexin decoction, a herbal therapeutic agent commonly used in traditional Chinese medicine, is recognized for its beneficial effects on diabetic nephropathy exerted through the combined action of multiple components, including Rhizoma Coptidis alkaloids (A), Radix et Rhizoma Rhei polysaccharides (P), and Radix Scutellaria flavones (F). Our previous studies have shown that a combination of A, P, and F (APF) exhibits renoprotective effects against diabetic nephropathy. This study was aimed at determining the effects of APF on renal fibrosis in diabetic nephropathy and elucidating the underlying molecular mechanisms.

View Article and Find Full Text PDF

Ethnopharmacological Relevance: Xiexin decoction (XXD) has been used as a treatment for diabetes mellitus for more than 1300 years. XXD constituents with protective effects against diabetic nephropathy (DN) include Rhizoma Coptidis alkaloids (RA), Radix et Rhizoma Rhei polysaccharides (RP), and Radix Scutellaria flavones (RF). The aim of the study is to investigate the effects of combinations of RA, RP, and RF on DN and their mechanisms of action.

View Article and Find Full Text PDF

Tangcao pill is commonly applied in adjuvant and even alternative therapy for patients with AIDS. However, the herb contains complex ingredients, but with unknown effect against anti-HIV drug and unknown function. Because CYP450 emzyme is the main metabolic enzymes of the drug, it is of important significance to study the regulation of CYP450 enzymes before and after the combined administration of Tangcao pill and EFV.

View Article and Find Full Text PDF

Rationale: An effective and safe treatment of insomnia in patients with neuropathic pain remains an unmet need. Melatonin and its analogs have been shown to have both analgesic and hypnotic effects; however, capacity of them on sleep disturbance with neuropathic pain as well as the precise mechanism is unclear.

Objective: The present study evaluated effects of piromelatine, a novel melatonin receptor agonist, on sleep disturbance in a neuropathic pain-like condition as well as the underlying mechanisms.

View Article and Find Full Text PDF

In Chinese medicine, Xiexin decoction (XXD) has been used for the clinical treatment of diabetes for at least 1700 years. The present study was conducted to investigate the effective ingredients of XXD and their molecular mechanisms of antidiabetic nephropathy in rats. Rats with diabetes induced by high-fat diet and streptozotocin were treated with XXD extract for 12 weeks.

View Article and Find Full Text PDF
Article Synopsis
  • - This study explores how the aqueous extract of Schisandra chinensis Baill and its compounds (kadsurin, schisandrin A, B, and schisandrol B) affect the activity of the CYP3A enzyme in rats through both in vivo and in vitro experiments.
  • - Results indicate that the aqueous extract of WWZ initially inhibits CYP3A activity after short-term administration but shows an inductive effect after prolonged exposure.
  • - Kadsurin demonstrated a dose-dependent inhibition of CYP3A activity, while schisandrin A, B, and schisandrol B significantly increased CYP3A1 mRNA expression in rat liver cells, highlighting their potential effects on liver metabolism.
View Article and Find Full Text PDF

Aim: To investigate the effect of recombined human glucagon-like peptide 1 (rhGLP-1 [7-36]) on the secretion and expression of amylin in Goto-Kakizaki (GK) rats.

Methods: The GK rats were treated with rhGLP-1 (7-36) 56 and 133 mug/kg subcutaneously for 12 weeks. The fasting and post-prandial blood glucose levels were measured.

View Article and Find Full Text PDF
Article Synopsis
  • * Data was collected from 549 patients through door-to-door surveys, and the Markov model helped assess the SFS process and its influencing factors.
  • * Results showed varying rates of SFS among different patient groups and indicated that higher pre-treatment glucose levels led to faster development of SFS, suggesting that simply switching sulphonylurea types won't delay this progression.
View Article and Find Full Text PDF

Background And Aim: Esomeprazole is the S-isomer of omeprazole, with a stronger acid suppressive effect than omeprazole. This open, randomized crossover study was designed to evaluate the effect of esomeprazole and another proton-pump inhibitor, rabeprazole, on intragastric pH in healthy Chinese.

Methods: Thirty-six healthy volunteers (26 men and 10 women, aged between 20 and 31 years) were enrolled.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined how the combination of norfloxacin and biphenylacetic acid affects IL-1beta levels in the brains of rats, particularly in relation to seizure activity.
  • Rats experienced clonic convulsions when given norfloxacin together with biphenylacetic acid, with EEG monitoring showing clear seizure patterns.
  • Results indicated that this combination transiently increased IL-1beta mRNA and protein in the prefrontal cortex and hippocampus, suggesting these regions are crucial in mediating seizures triggered by norfloxacin.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to identify high-risk factors for postoperative upper gastrointestinal bleeding in neurosurgery patients to improve prevention strategies.
  • A logistic regression analysis was conducted on 1,500 neurosurgical patients, resulting in 1,430 valid questionnaires revealing a 5.24% overall incidence of upper GI bleeding post-surgery.
  • Key risk factors included being over 50 years old, male, having a Glasgow Coma Score below 10, and the presence of certain brain lesions, particularly in the brainstem or fourth ventricle.
View Article and Find Full Text PDF

Purpose: The study was to assess the quality of life (QOL) of the elderly diabetes mellitus (DM) in Shanghai community and to screen the possible risk factors.

Methods: A total of 951 patients with elderly DM and 1007 elderly subjects with normal glucose tolerance from the same community as control group were enrolled in the study. A door-to-door retrospectively epidemiological survey was used to collect data of QOL, demographic, and diabetic information.

View Article and Find Full Text PDF

Background: Nonselective muscarinic receptor antagonist, atropine, was believed to inhibit myopic progression. The purpose of this study was to determine the efficacy, through topical administration, of the M1-selective muscarinic antagonist pirenzepine in preventing experimentally induced form-deprivation myopia in guinea pigs.

Methods: Fifty-three guinea pigs, which underwent monocular deprivation with their eyelids sutured, were divided into 6 groups.

View Article and Find Full Text PDF

Aim: To study the relationship between chondrotoxicity and toxicokinetics of ciprofloxacin (CPFX).

Methods: Rats, 4-week old, were treated with CPFX 0, 400, 800, and 1200 mg/kg ig once daily on seven consecutive days. The knee joint cartilage was examined histopathologically.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to identify risk factors for adverse drug reactions (ADRs) caused by non-steroidal anti-inflammatory drugs (NSAIDs) in patients with arthropathy in Shanghai.
  • Researchers used a door-to-door retrospective survey to gather demographic, medical, and lifestyle data from 1002 randomly selected patients, finding high ADR incidence rates between 46.7% and 66.2% for various NSAIDs.
  • The results indicated that risk factors for ADRs differed among NSAIDs, with a family history of ADRs being a significant risk factor for four specific NSAIDs, underscoring the need for individualized assessments.
View Article and Find Full Text PDF

Objective: To observe the rate of efficacy and adverse drug reaction of non-steroidal anti-inflammatory drugs (NSAIDs) in the population with osteoarthritis and rheumatoid arthritis, based on available clinical data.

Methods: Using Meta analysis to evaluate the data of effect and safety profile of NSAIDs from 19 articles on randomized clinical trials published from 1990 to 2001 in Chinese journals. The total number of patients enrolled for evaluation on rates of effectiveness and adverse drug reaction were 1 732 and 2 925, respectively.

View Article and Find Full Text PDF

Aim: To study the neurotoxicity and toxicokinetics of norfloxacin (NFLX) in freely moving rats.

Methods: Rats were assigned randomly to four treatment groups that received a single iv dose of 50, 100, 200 mg/kg of NFLX and 0.9 % saline, respectively.

View Article and Find Full Text PDF

The effects of four fluoroquinolones (sparfloxacin, fleroxacin, ofloxacin and levofloxacin) on K(+) currents were investigated in pyramidal neurons acutely isolated from rat hippocampus, to evaluate their relative potencies for inhibiting these channels. Using patch-clamp electrophysiological techniques, we found that all four compounds inhibited the delayed rectifier K(+) current (I(K)), but with different potencies. Sparfloxacin was the most potent compound, displaying an IC(50) value of 6.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionjgd1d8tsn26gk5hlsk32or7p7cc2g5c9): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once