Publications by authors named "Neng-Lian Li"
This study aims to identify the active components and the mechanism of Jingqi Yukui Capsules(JQYK) in the treatment of gastric ulcer based on network pharmacology, and verify some key targets and signaling pathways through animal experiment. To be specific, first, the active components and targets of JQYK were retrieved from a Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP), and the targets of gastric ulcer from GeneCards and Online Mendelian Inheritance in Man(OMIM) with the search term "gastric ulcer". The common targets of the two were the potential targets of the prescription for the treatment of the di-sease.
View Article and Find Full Text PDFTumor growth and metastasis are closely related to angiogenesis. Basic fibroblast growth factor(bFGF) is an angiogenic factor, and up-regulated expression of bFGF plays a crucial role in the development and metastasis of melanoma. Therefore, in this study, we sought to achieve antitumor activity by immunity targeting bFGF which would inhibit tumor angiogenesis and simultaneously induce bFGF specific cytotoxic T lymphocytes to kill melanoma cells.
View Article and Find Full Text PDFObjective: To investigate the effect of total flavonoids of Hedysarum polybotry on the proliferation, cell cycle, and expressions of p21(Ras) and proliferating cell nuclear antigen (PCNA) gene in erythroleukemia cell line K562.
Methods: The effect of total flavonoids of Hedysarum polybotry on K562 cell line survival was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) reduction assay. The time- and dose-dependent manner was also observed.
Actions of genistein on contractile response of smooth muscle isolated from guinea pig gallbladder.
Hepatobiliary Pancreat Dis Int
December 2009
Article Synopsis
- Defective contractile motility of the gallbladder contributes to gallstone formation, with estrogen potentially increasing this risk; genistein, a phytoestrogen, was tested for its effects on gallbladder smooth muscle.
- In an experiment, guinea pig gallbladders were used to measure contractile responses to varying concentrations of genistein, while also evaluating mechanisms via specific antagonists.
- Results showed that genistein decreased both the resting tension and contractile responses of gallbladder smooth muscle, suggesting it could play a role in gallstone formation by relaxing the muscle, particularly by affecting responses to acetylcholine.