Carvedilol blockage of delayed rectifier Kv2.1 channels and its molecular basis.

Previous studies indicated that one of the action targets of carvedilol is the voltage-gated potassium (Kv) channel, which has a fundamental role in the control of electrical properties in excitable cells. It is not clear whether this compound exerts any actions specifically on delayed rectifier Kv2.1 channels.

Characterization and molecular basis for the block of Kv1.3 channels induced by carvedilol in HEK293 cells.

Carvedilol is a non-selective β-adrenoreceptor antagonist and exhibits a wide range of biological activities. The voltage-gated K (Kv) channel is one of the target ion channels of this compound. The rapidly activating Kv1.

Inhibitory effects of cholinesterase inhibitor donepezil on the Kv1.5 potassium channel.

Kv1.5 channels carry ultra-rapid delayed rectifier K currents in excitable cells, including neurons and cardiac myocytes. In the current study, the effects of cholinesterase inhibitor donepezil on cloned Kv1.

Molecular cloning and characterization of two manganese superoxide dismutases from Miscanthus × giganteus.

Six MnSOD genes were isolated from five Miscanthus species. MgMnSOD1 functions in mitochondria and MgMnSOD1 seems to be the main MnSOD gene involved in stress response of M. × giganteus.