Publications by authors named "Nenad Vasilic"
Background: Hemoglobin, Albumin, Lymphocyte, and Platelet Score (HALP) is an accessible score that is easily reproducible from routine laboratory testing while also reflecting patients' immune-nutritional status. Along with other immuno-nutritional scores, such as the Prognostic Nutrition Index (PNI), HALP has been associated with a number of clinical and pathological features. The goal of our study was to evaluate the prognostic utility of HALP and PNI scores in testicular germ cell cancer (GCT) patients.
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- - The study examined the impact of multifocality (presence of multiple tumor sites) in 280 testicular cancer patients who underwent radical orchiectomy, aiming to find connections with clinical and pathological traits.
- - Multifocality was found in 15.7% of patients and was linked to smaller primary tumors (average 20.0 mm) compared to those with a single tumor focus (average 30.0 mm), with a notable number of multifocal patients having tumors under 2 cm.
- - Despite these associations, the study concluded that multifocality does not significantly affect the prognosis for advanced clinical stages of testicular cancer, as it wasn't a notable risk factor in either seminoma or non-seminoma
In contemporary clinical practice, biomarkers are indispensable in the assessment and management of oncological patients. Although established serum tumor markers (beta human chorionic gonadotropin (bHCG), alpha fetoprotein (AFP), and lactate dehydrogenase (LDH)) have an indisputably important role in the management of patients with testicular cancer (TC), the application of these tumor markers may be accompanied with certain limitations, implying the need for additional biomarkers. Contrary to TC, there is a lack of established serological biomarkers for penile cancer (PC) and the management of this urological malignancy is based on multiple clinicopathological parameters.
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