Publications by authors named "Nenad Grujovic"

This study focused on preparing composite nanomats by incorporating silver nanoparticles (AgNPs) in polyvinylidene fluoride (PVDF) nanofibers through the electrospinning process. A short review of piezoelectric PVDF-related research is presented. PVDF is known for its biocompatibility and piezoelectric properties.

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Article Synopsis
  • This paper examines recent advancements and uses of silicone in ophthalmology, particularly focusing on intraocular lenses (IOLs) and their properties.
  • It highlights the need for better methods to assess the mechanical and in vivo performance of silicone IOLs to ensure their safety and long-term effectiveness.
  • The review discusses innovations in surface modifications and nanotechnology to enhance IOLs' biocompatibility and therapeutic functions, although more clinical trials are needed to bring these technologies into practice.
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Background: The biological properties of silicone elastomers such as polydimethylsiloxane (PDMS) have widespread use in biomedicine for soft tissue implants, contact lenses, soft robots, and many other small medical devices, due to its exceptional biocompatibility. Additive manufacturing of soft materials still has significant challenges even with major advancements that have occurred in development of these technologies for customized medical devices and tissue engineering.

Objective: The aim of this study was to develop a mathematical model of tangential stress in relation to shear stress, shear rate, 3D printing pressure and velocity, for non-Newtonian gels and fluids that are used as materials for 3D printing.

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This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems.

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This study was conducted on different models of biodegradable SMP (shape-memory polymer) scaffolds. A comparison was conducted utilizing a basic FDM (fused deposition modeling)/MEX (material extrusion) printer with a standard printing technique and a novel, modified, four-axis printing method with a PLA (poly lactic acid) polymer as the printing material. This way of making the 4D-printed BVS (biodegradable vascular stent) made it possible to achieve high-quality surfaces due to the difference in printing directions and improved mechanical properties-tensile testing showed a doubling in the elongation at break when using the four-axis-printed specimen compared to the regular printing, of 8.

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This paper deals with the selection of the optimal material for railway wagons, from among three different steel and three aluminium based materials, by using four different Multicriteria Decision Making Methods (MCDM) and comparing their ranking of the materials. We analysed: Dual-Phase 600 steel, Transformation-Induced Plasticity (TRIP) 700 steel, Twinning-Induced Plasticity (TWIP) steel, Aluminium (Al) alloys, Al 6005-T6, and Al 6082-T6, and porous Al structure with closed cells. Four different MCDM methods were used: VIKOR, TOPSIS, PROMETTHEE and the Weighted aggregated sum product assessment method (WASPAS).

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This paper deals with the experimental and numerical study of closed-cell aluminum-based foam under compressive loading. Experimental samples were produced by the gas blowing method. Foam samples had an average cell size of around 1 mm, with sizes in the range 0.

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We have studied an application of the Voronoi tessellation method in the modeling of open-cell aluminium foam under uniaxial compressive loading. The Voronoi code was merged with computer-aided design (CAD) for converting the polyhedral model into an irregular open-cell cellular structure to create porous samples for compression testing simulations. Numerical simulations of the uniaxial compression uniformly over the upper surface of the sample in the -axis direction at a constant 20 N load was realised.

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We report a case of successful sternum and ribs/cartilage resection and chest wall reconstruction with a methacrylate implant produced using a three-dimensional model in a patient with a tuberculotic mass in this region. Clinical and radiologic follow-up 2 years after surgery showed excellent cosmetic and functional outcome.

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Deformation behavior of polymethyl methacrylate (PMMA) bone cement is explored using microindentation. Two types of PMMA bone cement were prepared. Vacuum treated samples were subjected to the degassing of the material under vacuum of 270 mbar for 35 s, followed by the second degassing under vacuum of 255 mbar for 35 s.

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The paper presents a case where an implant for a part of the sternum (with costal cartilages) affected by cancer was created and implanted by using the specific reverse modeling method and solid free-form fabrication. The method provides surgeons with a fast and reliable tool for tissue engineering and implantation and therefore improves the quality of life for patients. Digital images of healthy sternum samples were used to develop a reverse modeling algorithm that semi-automatically generates a necessary and sufficient simplification of the tissue geometry to be fabricated in an inexpensive and applicable manner.

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