Novel Knowledge of Macrolide Resistance in by Azithromycin Exposure.

The rise of macrolide-resistant (MRMP), marked by point mutations in the 23S rRNA gene, poses a growing global concern since its initial detection in 2001. The prominence of the A2063G mutation during this emergence remains unexplained. This study aimed to clarify the possibility of detecting MRMP from recent clinical macrolide-susceptible through exposure to azithromycin (AZM), which has a long half-life and was launched immediately before the first MRMP detection.