[Therapy result of malignant tumors of the paranasal sinuses in patients treated at the metropolitan onco-radiologic centre of Budapest. Period under review: 1946-1974 (author's transl)].

A report is given on the therapy results of 301 patients with ethmoidomaxillary tumors treated at the Metropolitan Onco-Radiologic Centre of Budapest between 1946 und 1974. Most of these patients were in an advanced stage when the first diagnosis was established. The five-year survival rate of all stages was 27%, which does not strongly differ from the average value of 30% mentioned in literature.

Influence of hormone concentration and time factor on development of receptor memory in a unicellular (Tetrahymena) model system.

1. Treatment of Tetrahymena pyriformis cells with diiodotyrosine (T2) gave rise to a considerable, concentration-dependent increase of the growth rate within the range of 10(-15) and 10(-9) M, but did not influence it at the level of 10(-18) M. 2.

Development and persistence of receptor 'memory' in a unicellular model system.

A single exposure of Tetrahymena to diiodotyrosine stimulated replication of the unicellular organism significantly relative to the control. The stimulatory effect tended to decrease with progressing time, but was still demonstrable after as many as 500 generations. Reexposures to diiodotyrosine also enhanced cell growth, indicating the existence of a receptor 'memory' in respect to the initial exposure, but their effect tended to decline soon after initial stimulation, and did not, in all probability, contribute to the preservation of the 'memory' which itself tends to vanish gradually in due course.

Involvement of selection and amplification mechanisms in hormone receptor development in a unicellular model system.

It was demonstrated earlier, that long lasting exposure of Tetrahymena to a hormone (histamine) resulted in an increased responsiveness to a later re-exposure. However, it was difficult to establish whether selection or amplification plays a role in receptor differentiation. As diiodotyrosine (T2) enhances the growth of Tetrahymena, in the present experiment the effect of T2-treatment on a long-term culture of Tetrahymena pyriformis was analysed by mathematical-statistical methods to differentiate the effects of selection and amplification mechanisms on hormone receptor development.

[Treatment experience with cervix uteri tumors].

During the period of 1946-1972 5279 patients with cervical cancer were treated, which data were processed by an electronic computer. In 83.6% of cases squamous non-keratoid cancer was revealed histologically.

Experimental study of hormone receptor development in a unicellular model system.

It was shown earlier that diiodotyrosine (T2) stimulates the growth of Tetrahymena. In the present study clonal populations of Tetrahymena, derived from subcultures propagated in the presence of T2, showed a highly significant increase of intra-clone variance over the control, while inter-clone variation was significant, but not decisive. This suggests that genetic factors play a smaller role in the development of the cell membrane receptor pattern tha the genetic variability of the membrane itself, which seems to account for the stabilization of the adequate receptors on first exposure to a hormone.

Receptor amplifying effect of serotonin and serotonin analogues in a protozoan (Tetrahymena) model system.

A 72-hour treatment of Tetrahymena with serotonin analogues at a concentration of 10(-9) mmole/l resulted in a decrease of the reproduction rate, whereas serotonin itself was ineffective. On the second exposure to antagonists, cellular division was enhanced but its rate remained around or below the control value, while the second exposure to serotonin produced a more marked effect than the first one did, which finding implies a receptor amplification. The most pronounced receptor amplification was caused by the first exposure to serotonin.

Enhancement of the sensitivity of Tetrahymena to a second hormonal influence by hormone pretreatment.

Diiodotyrosine and serotonin enhance the growth of Tetrahymena. A second exposure of the unicellular to these hormones accounts for a still greater increase of its growth rate, probably due to the amplification of the receptor induced by the first exposure.

Changes of receptor cooperation in Tetrahymena by re-exposure to hormones.

The hormone combination epinephrine + diiodotyrosine inhibited the growth of Tetrahymena cells on first exposure, but stimulated it markedly on re-exposure. It appears that amplification of the receptor by the hormone does take place at the first encounter, regardless of whether the response of the cells was positive or negative. The amplifying effect persists over several generations.

New primary malignant tumors in patients treated for carcinoma of the uterine cervix or corpus.

Subsequent primary malignancy was revealed in 1.8 per cent of 2, 689 cases with cervical and in 1.7 per cent of 773 cases with corpus carcinoma.

Effect of hormones and related compounds on the multiplication of Tetrahymena.

The vertebrate hormone triiodothyronine, the commonly occurring animal and plant hormone serotonin, and the plant alkaloid gramine, chemically related to the latter, stimulated the multiplication of Tetrahymena. Neither epinephrine nor gibberellin had such an effect. These experimental observations support the previous suggestion that unicellular animals possess structures capable of responding to certain hormones, which do not seem to elicit specific responses of the unicellular animal, but rather act through the activation of certain general functions.

[Therapeutic results achieved in 1366 patients with corpus uteri carcinomas treated between 1946 and 1972].

A report is given on 1366 patients with tumour of the uterine body. A computer was used for evaluation purposes. The 5-year survival rate relating to all stages of the disease was 62.

[Changes in treatment results of 5279 cervix tumor patients between 1946 and 1972].

Results of the treatment of 5279 cervix tumour patients between 1946--1972 are reported. The assessment was performed by computer analysis of the material. There was a parallel rise in the 5 years survival of patients with the growth of radiotherapeutical equipment, mainly in extensive cases.

[Quantitative changes of glyco- and mucoproteins in the serum of patients with carcinoma of the uterus during treatment].

The mutations of serum glycoproteid and mucoproteid levels were examined in 40 patients with uterine cancer before, during and 4 years after treatment. In all the patients having become symptom-free the glycoproteid and mucoproteid concentration, that had shown an initial increase before, returned to normal in the course of successful treatment. There could be found no connection between the tumor extension and the otherwise increased serum values in carcinoma of cervix and uterus of stage I.