Pedigree-Based Description of Danubia Alba Rabbit Breed Lines.

The diversity of livestock animal breeds is an integral part of global biodiversity and requires careful management for sustainability and future availability. Avoiding inbreeding is a crucial aspect of mating of breeding animals. Our aims were to describe the quality of the pedigree, generation interval, gene origin, inbreeding, and effective population size of Danubia Alba rabbit lines.

Genomic Analysis of Strains Originating from Hungarian Rabbit Farms Reinforce the Clonal Origin of Various Virulence Types.

Staphylococcosis is one of the most important infectious diseases in rabbit medicine, especially in commercial farming. Previous studies revealed the existence of virulent variants adapted to rabbits. Typical and atypical, highly virulent as well as low virulent variants have been isolated and reported from industrial units in all major rabbit-meat-producing countries.

Outbreaks of a Methicillin-Resistant Clone ST398-t011 in a Hungarian Equine Clinic: Emergence of Rifampicin and Chloramphenicol Resistance After Treatment with These Antibiotics.

Between July 2011 and May 2016, a total of 40 strains originating from 36 horses were confirmed as methicillin resistant (methicillin-resistant [MRSA]) in a university equine clinic. An additional 10 MRSA strains from 36 samples of clinic workers were obtained in October 2017. The first equine isolate represented the sequence type ST398, -type t011, and SCC IV.

Draft Genome Sequence of an Atypical Highly Virulent Rabbit Strain.

Rabbit staphylococcosis is one of the most important diseases in industrial rabbit production. We report here the draft genome sequence of strain 380/11, an atypical highly virulent (aHV) rabbit strain.

Re-emergence of bovine haemorrhagic septicaemia in Hungary.

This paper reports an outbreak of haemorrhagic septicaemia caused by Pasteurella multocida B:2 in beef calves, a disease that has not been described in the Hungarian literature since 1943, and has not been reported to the World Organisation For Animal Health (OIE) since 1970. Acute haemorrhagic septicaemia was confirmed in beef calves on one small farm, and was suspected on two further nearby holdings with concomitant unexplained losses. The source of the infection could not be determined.

Virulence type and tissue tropism of Staphylococcus strains originating from Hungarian rabbit farms.

Staphylococcosis has a major economic impact on rabbit farming worldwide. Previous studies described a highly virulent variant, which is disseminated across Europe. Such strains are reported to be capable of inducing uncontrollable outbreaks.

Draft Genome Sequence of a Highly Virulent Rabbit Staphylococcus aureus Strain.

We report the draft genome sequence of Staphylococcus aureus Sp17, a typical highly virulent (HV) rabbit strain. As current medicine apparently fails to effectively reduce disease and economical losses caused by this organism, it is essential to gain better insight on its genomic arrangement.

Efficacy and tolerability of early administration of valnemulin hydrochloride premix on epizootic rabbit enteropathy.

A blinded, randomised, placebo-controlled clinical trial was conducted to evaluate the efficacy and safety of valnemulin hydrochloride premix during an outbreak of epizootic rabbit enteropathy (ERE) when administered in feed for 21 consecutive days after confirmation of the first ERE case. Administration of valnemulin at 20 and 35 parts per million (ppm) significantly reduced mortality by 11% and 7.6%, respectively, when compared with the non-medicated control group (23% mortality).

Sarcocystis-infection of cattle in Hungary.

Background: Reports on Sarcocystis-infection of cattle are outdated or lacking in many European countries, including those in the Central-Eastern part of the continent. Therefore, to assess the prevalence of Sarcocystis spp. among bovids in Hungary, a countrywide survey was initiated.

Rietveld refinement in the routine quantitative analysis of famotidine polymorphs.

Accurate, precise and reliable X-ray powder diffraction method was developed for the quantitative determination of famotidine polymorphic forms in their binary mixtures, which slightly outperforms the previously established Raman method. The study highlights the advantage of focused beam transmission geometry in diminishing the effect of preferred orientation in general, and the straightforward transmission foil sample preparation technique in facilitating high-throughput measurements in particular. This combination can provide good quality data for Rietveld refinement which assures more reliable quantitative results than utilizing intensity ratios of selected single reflections.

Quantitative determination of famotidine polymorphs: X-ray powder diffractometric and Raman spectrometric study.

X-ray powder diffractometric and Raman spectrometric methods were developed for quantitative measurement of the polymorphic forms of famotidine in their mixtures. This study aims to deduce some useful conclusions regarding quantitative polymorph analysis, which could also be utilized in industrial practice. Both form A and form B of famotidine possess specific X-ray diffraction reflections as well as characteristic Raman vibrational bands, which permits simple determination of the phases in their mixtures.

Quantifying low levels of polymorphic impurity in clopidogrel bisulphate by vibrational spectroscopy and chemometrics.

Vibrational spectroscopic methods were developed for quantitative analysis of Form II of clopidogrel bisulphate in Form I and Form II polymorphic mixtures. Results show that both IR and Raman spectroscopy combined with chemometrics are suitable to quantify low levels of Form II in Form I, down to 2 and 3%, respectively, with less than 1% limit of detection. Different preprocessing and multivariate methods were applied for spectral processing and were compared to find the best chemometric model.

Polymorph transitions of bicalutamide: a remarkable example of mechanical activation.

Bicalutamide, an active pharmaceutical ingredient possessing antiandrogenic activity, is known to exhibit polymorphism. The higher melting Form I relates monotropically to the lower melting Form II. The amorphous form can be easily produced by quench cooling the melt, but it is known to crystallize spontaneously to Form II at room temperature within days.

Stevens-Johnson syndrome as an unusual adverse effect of azithromycin.

Stevens-Johnson syndrome mostly involves the skin and mucous membranes. The diagnosis is made when the characteristic rash appears 1 to 3 weeks after exposure to a known stimulus and cannot be explained by some other diagnosis. A 62-year-old woman was admitted for evaluation of toxo-allergic dermatitis and collagenosis.