Publications by authors named "Nemanja Z Petrovic"
Population toxicokinetics of carbamazepine and its metabolite carbamazepine-10,11-epoxide in adults.
Expert Opin Drug Metab Toxicol
August 2024
Article Synopsis
- Carbamazepine is a widely used medication for seizures, but little is known about how it behaves in cases of overdose, prompting a study on its toxicokinetics in self-poisoning patients.
- The research utilized NONMEM software to develop a model analyzing the elimination and distribution of carbamazepine and its metabolite, carbamazepine-10,11-epoxide, based on patient data.
- Findings suggested that the ability of adults to eliminate these substances after an overdose is linked to high levels of inflammation markers (CRP) and psychological treatment measures like sedation.
Background: Premature rupture of membranes (PROM) is defined as the leakage of amniotic fluid before the onset of labor and delivery contractions. Some studies found that women who experienced PROM had significantly lower vitamin C blood levels than those who did not, while others found no significant differences. Previous systematic reviews and meta-analyses on the efficacy of vitamin C in the prevention of PROM had conflicting results.
View Article and Find Full Text PDFBackground: Recently, case reports of priapism associated with the use of some anti-seizure medications began to emerge in the literature. We aimed to investigate if there is a potential safety signal of priapism among individual anti-seizure medications and to search the literature for relevant published cases.
Research Design And Methods: We conducted a disproportionality analysis using OpenVigil 2.