Performance of Phenotypic Tests to Detect β-Lactamases in a Population of β-Lactamase Coproducing Isolates.

 This study aimed to evaluate the performance of routinely used phenotypic tests to detect β-lactamase production in isolates coproducing multiple β-lactamase types.  Commonly used phenotypic tests for the detection of extended spectrum β-lactamases (ESBL), AmpC β-lactamase, and carbapenemases were compared with detection and sequencing of β-lactamase genes (as the reference test) in 176 uropathogenic coproducing multiple β-lactamases from two hospitals in the Western Province of Sri Lanka.  Majority of the isolates (147/176, 83.

Antimicrobial Resistance Genes, Virulence Genes, and Associated Mobile Genetic Elements of Eight Multidrug-Resistant Isolated from Hospital-Acquired Urinary Tract Infections in Sri Lanka.

The study describes the first isolation of multidrug-resistant (MDR) ST16, ST131 (Esc), and subsp. steigerwaltii ST93 ( complex [ECC]) in Sri Lanka. Eight MDR strains of uropathogenic Enterobacterales isolated from hospital acquired urinary tract infections (UTIs) were analyzed using genomic sequencing and comparative genomics.

Typhoid Fever due to Extended Spectrum -Lactamase-Producing Serovar Typhi: A Case Report and Literature Review.

Emergence of cephalosporin-resistant strains of serovar Typhi is a cause of concern in the management of enteric fever. Cephalosporin resistance in species is mainly due to the production of extended-spectrum -lactamases (ESBLs). The majority of ESBLs in serovar Typhi are derivatives of the TEM, SHV, and CTX-M -lactamase families.

Non-dermatophyte mold onychomycosis in Sri Lanka.

Dermatophytic and non-dermatophytic onychomycosis (NDM) was indistinguishable clinically in our case series. Making a clinical diagnosis of onychomycosis without mycology is the routine practice in Sri Lanka. The prevalence of NDM (45.

Onychomycosis caused by Fusarium sp in Sri Lanka: prevalence, clinical features and response to itraconazole pulse therapy in six cases.

Objectives: The aims of our study were to ascertain the proportion of Fusarium onychomycosis among patients with suspected onychomycosis, to record clinical features and to assess the efficacy of itraconazole pulse therapy in treatment.

Methods: Six patients with positive isolates of Fusarium sp were treated in an open, prospective manner with itraconazole: two pulses for fingernails and three pulses for toenails. Significant growth of Fusarium sp was considered when both microscopy of direct mounts in KOH and culture were positive for mold.

Fatal septicaemia caused by Chromobacterium violaceum.

We report a case of Chromobacterium violaceum septicaemia in a 10-year old boy admitted to hospital in September 2001, two weeks after he suffered a crush injury of the left foot. In spite of surgical debridement and antibiotics his condition worsened and he developed multiple liver and lung abscesses. He died one week after admission and a blood culture grew Chromobacterium violaceum.