Publications by authors named "Nelson Nicolasora"
Article Synopsis
- Cefiderocol is the first antibiotic that has dosing guidelines based on the effluent flow rates for patients undergoing continuous renal replacement therapy (CRRT).
- A study conducted on ICU patients receiving CRRT showed that cefiderocol concentrations fit well within a specific pharmacokinetic model, confirming its effectiveness and safety.
- The dosing recommendations led to optimal drug levels in all patients, which suggests it can be safely used to achieve the desired therapeutic effects.
Mpox, caused by infection with , usually presents as a mild, self-limited illness in immunocompetent persons that resolves within 2-4 weeks. Serious complications have been reported when mpox lesions involve vulnerable anatomic sites, such as the eye, and in those with substantial immunosuppression. We describe a patient with advanced human immunodeficiency virus infection and sustained viral shedding of mpox with ocular involvement, which resulted in vision loss.
View Article and Find Full Text PDFOcular Monkeypox - United States, July-September 2022.
MMWR Morb Mortal Wkly Rep
October 2022
Article Synopsis
- * Five patients developed ocular monkeypox between July and September 2022, receiving treatments like tecovirimat, with two patients having delays in care due to HIV-related complications.
- * Ocular monkeypox can threaten vision, so patients should practice hygiene to prevent self-inoculation, and healthcare providers should be aware of the condition for timely treatment and public health reporting.
Use of Industrial Filters by Health Care Workers During Shortages of N95 Respirators in Pandemic Times.
Infect Dis Clin Pract (Baltim Md)
September 2021
The coronavirus disease 2019 (COVID-19) pandemic has led to a significant shortage of personal protective equipment in multiple health care facilities around the world, with the highest impact on N95 respirator masks. The N95 respirator is a mask that blocks at least 95% of very small (0.3 μm) particles and is considered a standard for enhanced respiratory precautions.
View Article and Find Full Text PDFAntimicrobial dosing in patients receiving continuous renal replacement therapy is a continued clinical challenge. We describe a case of a patient receiving cefiderocol 2 g intravenously every 8 hours as a 3-hour infusion for a multidrug-resistant pneumonia and bacteremia while undergoing continuous venovenous hemodiafiltration. The clinical course and cefiderocol pharmacokinetics are described.
View Article and Find Full Text PDFStaphylococcus aureus has long been recognized as a cause of acute bacterial parotitis. A case of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) parotitis is presented, highlighting the emergence of this increasingly important pathogen to cause a wide variety of infections. Also reviewed are the salient clinical and microbiologic features of this novel infection.
View Article and Find Full Text PDFThis article reviews principles of recognition and management of a selection of commonly encountered infectious disease emergencies, including sepsis, necrotizing soft tissue infections, acute meningitis, and the emerging issue of severe Clostridium difficile colitis. Less common but potentially deadly environmentally acquired or zoonotic pathogens are discussed, as are special patient populations, including the febrile returning traveler and the asplenic patient.
View Article and Find Full Text PDFBackground: No national policy requires health care providers to discuss with hospitalized patients whether the latter would want cardiopulmonary resuscitation (CPR) or mechanical ventilation (MV) in the event of cardiopulmonary failure.
Objective: To determine whether hospitalized patients are willing to discuss end-of-life issues and choose whether to receive CPR and MV.
Design: Prospective randomized trial.