Publications by authors named "Nelson Fernando Quallio Marques"
Expansion of Oropouche virus in non-endemic Brazilian regions: analysis of genomic characterisation and ecological drivers.
Lancet Infect Dis
November 2024
Article Synopsis
- Oropouche virus (OROV) is an arbovirus that has spread beyond its usual Amazon basin habitat, with a significant outbreak occurring in the Brazilian Amazon during 2023-24, leading to cases in other Latin American countries.
- A genomic and epidemiological study from January 2023 to July 2024 showed a higher incidence of OROV in smaller municipalities, and a correlation between agricultural area sizes, particularly banana and cassava plantations, and the number of OROV cases.
- Phylogenetic analysis indicated multiple exportation events of a new reassortant lineage of OROV from Amazon regions to other parts of Brazil occurred between January and March 2024.
The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. In this study, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia and Ecuador (2008-2021).
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- - Researchers analyzed 3 local cases and 1 imported case of dengue virus serotype 3 in Brazil, highlighting its return after 15 years.
- - The cases were reported from two different regions in Brazil, North and South.
- - A new Asian lineage of the virus was identified, which raises concerns about potential future outbreaks in the Americas.
Unlabelled: Different products of plant Morinda citrifolia L. (noni) have been marketed and used around the world based on properties described by Polynesian people that use them for more than 2000 years. Marketing of these products is based on their presumptive phytotherapic properties.
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