Publications by authors named "Nels Nielson"
Article Synopsis
- S. pneumoniae has three neuraminidases (NanA, NanB, NanC) that affect how these bacteria interact with host cells by cleaving sialic acid from their surfaces.
- Research primarily concentrated on NanA, but a study found that targeting all three is necessary to prevent damage to lung cell surfaces during infection.
- Despite successfully blocking desialylation with specific antibodies (mAbs), the study showed no significant impact on survival or bacterial load in a mouse model, indicating that these neuraminidases may not play a crucial role in this particular pneumonia model.
LukGH (LukAB) is a potent leukocidin of Staphylococcus aureus that lyses human phagocytic cells and is thought to contribute to immune evasion. Unlike the other bi-component leukocidins of S. aureus, LukGH forms a heterodimer before binding to its receptor, CD11b expressed on professional phagocytic cells, and displays significant sequence variation.
View Article and Find Full Text PDF