Publications by authors named "Neloy Kundu"
Exosomes are extracellular vesicles within the nanosized range that play roles in intercellular communication and thus have certain biological activities. The secretory signaling communication mechanism is an efficient way of exchanging information between cells and has been investigated as nature's therapeutic drug carriers. This review will summarize the potential of exosomes as therapeutic tools and drug delivery vehicles for corneal pathologies.
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- Schizophrenia can impair thinking and motivation, and the study investigates the effects of daidzin (DZN) on mice to see if it improves cognitive functions like attention and memory.
- A series of behavioral tests, including marble burying and swimming tasks, were conducted on Swiss mice divided into groups receiving different doses of DZN and a standard drug called olanzapine (OLN).
- Results showed that DZN significantly improved attention and memory-related behaviors, particularly in combination with OLN, while in silico analysis revealed that DZN has strong interactions with serotonin and dopamine receptors, suggesting a potential mechanism for its effects.
The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and reactive oxygen species (ROS) sensitive Ca-permeable cation channel has a vital role in surviving the cell as well as defending the adaptability of various cell groups during and after oxidative stress. It shows higher expression in several cancers involving breast, pancreatic, prostate, melanoma, leukemia, and neuroblastoma, indicating it raises the survivability of cancerous cells. In various cancers including gastric cancers, and neuroblastoma, TRPM2 is known to conserve viability, and several underlying mechanisms of action have been proposed.
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