Publications by authors named "Nelly M Oliver"
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations.
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- The study explores challenges in using whole-exome sequencing (WES) for cancer precision medicine, emphasizing the need to evaluate genomic alterations systematically for therapeutic relevance.
- It involved 165 patients with metastatic colorectal and lung adenocarcinomas, assessing DNA from tumor biopsies and blood samples to rank genomic changes by their clinical importance.
- Results showed that a significant majority of genomic alterations lacked strong clinical evidence, highlighting the need for improved interpretive tools to better support decision-making in precision medicine.