Publications by authors named "Nelly Guilain"
Objective: Among specific autoantibodies in DM, the anti-small ubiquitin-like modifier activating enzyme (SAE) antibody is rare. We aim to describe the clinical characteristics, cancer prevalence, and muscle pathology of anti-SAE-positive DM.
Methods: Patients with a diagnosis of DM and sera positive for the anti-SAE antibody were recruited from 19 centres in this retrospective observational study.
Article Synopsis
- The study aimed to analyze the fatal effects of COVID-19 by examining the histopathological features in both ICU and non-ICU patients who died from the disease.
- A total of 20 patients underwent multiorgan biopsies, revealing significant pulmonary damage, with various levels of alveolar damage and differing rates of acute and chronic lesions between ICU and non-ICU groups.
- Findings also included the presence of viral RNA and associated viral replication markers in lung and kidney tissues, highlighting more severe lung and extrapulmonary injury in ICU patients compared to non-ICU patients.
Article Synopsis
- * The biopsies showed a distinct trabecular architecture with specific cell characteristics, and immunohistochemical analysis indicated low proliferation and expression of smooth muscle markers.
- * Preoperative diagnosis is challenging due to the lack of typical imaging features, and while there's no established treatment consensus, endoscopic resection is recommended for small tumors as a less invasive option.
Introduction: The profession of pathologist exposes to various risks, notably infectious, physical and chemical. The objective of this study was to make an inventory of these occupational risks to which pathologists are subjected and to evaluate the pathologies that they presented. A particular attention was given to microscopic and screen work as they can induce musculoskeletal or ophthalmic disorders, and stress-related psychological disorders.
View Article and Find Full Text PDFBackground/aim: The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context.
Materials And Methods: We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA).